基于处方模板的食管癌围手术期动态营养 支持的建立及应用评价

中国医药导刊 ›› 2022, Vol. 24 ›› Issue (6): 593-597.

基于处方模板的食管癌围手术期动态营养支持的建立及应用评价

张厚莉1，孟伟1，王启飞2，陈文文1，耿涛1，党和勤1，刘宝军3*

山东第一医科大学第二附属医院药剂科1，胸外科2，肿瘤科3，山东泰安 271000

收稿日期:2022-01-12 修回日期:2022-05-07 出版日期:2022-06-28 发布日期:2022-06-28
基金资助:
山东省中医药科技发展计划（项目编号：2019-0358；项目名称：基于JAK2-STAT3信号通路探讨花生红衣影响血小板生成的作用机制）；山东省医药卫生科技发展计划(项目编号：2018WS120；项目名称：房颤患者应用华法林抗凝管理质量评价指标的临床应用研究)

Establishment and Application Evaluation of Perioperative Dynamic Nutrition Support for Esophageal Cancer Patients Based on Prescription Templates

Department of Pharmacy1， Department of Thoracic Surgery2， Department of Oncology3， The Second Affiliated Hospital of Shandong First Medical University， Shandong Tai′an 271000， China

Received:2022-01-12 Revised:2022-05-07 Online:2022-06-28 Published:2022-06-28

摘要/Abstract

摘要： 目的：评价基于处方模板的食管癌围手术期动态营养支持治疗的有效性、安全性及经济性。方法：将2019年4~7月于我院实施基于处方模板的围手术期动态营养支持模式的食管癌患者作为实验组，将2018年4~7月于我院实施传统围手术期营养支持模式的食管癌患者作为对照组，比较两组患者住院期间营养指标、术后胃肠功能恢复时间、并发症发生率、住院时间及药品费用等指标。结果：实验组患者术后第7 d的血清白蛋白、前白蛋白水平均高于对照组（P<0.05）。与对照组相比，实验组患者平均住院天数更短（P<0.05），术后胃肠功能恢复时间差异无统计学意义（P>0.05）。实验组胃肠道并发症发生率低于对照组（P<0.05），感染及吻合口瘘等并发症发生率与对照组相比差异无统计学意义（P>0.05）。实验组患者住院期间药品费用较对照组有所降低，但差异无统计学意义（P>0.05）。结论：基于处方模板的围手术期动态营养支持的建立能有效改善食管癌患者营养状态，降低术后胃肠道并发症的发生率，同时缩短住院时间。

关键词: font-size:medium, ">处方模板；食管癌；营养支持；干预

Abstract: Objective：To evaluate the effectiveness， safety and economy of perioperative dynamic nutrition support for esophageal cancer patients based on prescription templates. Methods： Esophageal cancer patients who received perioperative dynamic nutrition support based on prescription templates in our hospital from April 2019 to July 2019 were seclected as the experimental group， and esophageal cancer patients who received the traditional perioperative nutrition support in our hospital from April 2018 to July 2018 were selected as the control group. The nutrition indicators， postoperative gastrointestinal function recovery time， occurrence rate of complication， duration of hospital stays and drug expense during the hospitalization were compared between the two groups. Results：The serum albumin and pre-albumin levels of patients in the experimental group were higher than those in the control group on the seventh day after surgery(P<0.05). The average duration of hospital stays of the experimental group was shorter than that of the control group(P<0.05). There was no statistical difference in the postoperative recovery time of gastrointestinal function between the two groups(P>0.05). The incidence of gastrointestinal complications in the experimental group was less than that in the control group(P<0.05)， and there was no statistical difference in the incidence of complications such as infection and anastomotic fistula between the two groups(P>0.05). The drug expense during the hospitalization of the experimental group were less than those in the control group， but the difference was not statistically significant(P>0.05). Conclusion： The establishment of perioperative dynamic nutrition support based on prescription templates can effectively improve the nutritional status of patients with esophageal cancer， decrease the incidence of postoperative gastrointestinal complications and shorten hospital stays.

Key words: font-size:medium, ">Prescription template； Esophageal cancer； Nutrition support treatment； Intervention

中图分类号:

张厚莉, 孟伟, 王启飞, 陈文文, 耿涛, 党和勤, 刘宝军. 基于处方模板的食管癌围手术期动态营养支持的建立及应用评价[J]. 中国医药导刊, 2022, 24(6): 593-597.

ZHANG Houli, MENG Wei, WANG Qifei, CHEN Wenwen, GENG Tao, DANG Heqin, LIU Baojun. Establishment and Application Evaluation of Perioperative Dynamic Nutrition Support for Esophageal Cancer Patients Based on Prescription Templates[J]. CHINESE JOURNAL OF MEDICINAL GUIDE, 2022, 24(6): 593-597.

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