干燥综合征患者血液系统损害与抗核抗体谱、抗心磷脂抗体的相关性分析#br#

摘要/Abstract

摘要： 目的：分析干燥综合征（SS）患者血液系统损害与抗核抗体谱（ANAs）、抗心磷脂抗体（ACL）的相关性。方法：选取我院SS患者126例为研究对象，将76例合并血液系统损害的患者纳入研究组，50例未合并血液系统损害的患者纳入对照组。分析研究组患者的血液系统损害情况，比较研究组和对照组ANAs和ACL阳性率。使用ROC曲线分析ANAs联合ACL对SS患者血液系统损害的评估价值。分析研究组贫血、白细胞（WBC）减少、血小板（PLT）减少患者ANAs和ACL的阳性率，以及单系损害与多系损害患者ANAs和ACL的阳性率。结果：研究组患者血液系统损害主要以单系损害为主（77.63%）。研究组患者抗SS-A、抗SS-B和ACL的阳性率均高于对照组（P＜0.05）。联合诊断对SS患者血液系统损害评估的AUC高于各指标单独诊断（P＜0.05）。贫血和WBC减少患者抗SS-A阳性率高于PLT减少患者（P＜0.05），WBC减少患者抗SS-B阳性率高于贫血和PLT减少患者（P＜0.05），PLT减少患者ACL阳性率高于贫血和WBC减少患者（P＜0.05）。单系损害患者ACL阳性率低于多系损害患者（P＞0.05）。结论：SS合并血液系统损害患者抗SS-A、抗SS-B以及ACL阳性率较高，以上指标≥2项阳性的患者更易于发生血液系统损害，其中合并ACL阳性的患者合并多系损害的风险较高。

关键词: font-size:medium, ">干燥综合征；血液系统损害；抗核抗体谱；抗心磷脂抗体

Abstract: Objective：Correlation of hematological disorders with antinuclear antibody spectrum and anticardiolipin antibodies in patients with Sjogren′s syndrome were analyzed. Methods：126 SS patients admitted in our hospital were enrolled，76 patients with hematological disorders were included in the study group， and 50 patients without hematological disorders were included in the control group. The hematological disorders of the patients in the study group was analyzed， and the positive rates of ANAs and ACL of the study group and the control group were compared. The ROC curve was used to analyze the evaluation value of ANAs combined with ACL on hematological disorders in patients with SS.The positive rates of ANAs and ACLs in patients with anemia， reduced WBC， and reduced PLT in the study group were compared， and the positive rates of ANAs and ACLs in patients with single-line damage and multi-line damage were compared. Results：The hematological disorders in the study group was mainly single-line damage (77.63%).The positive rates of anti-SS-A， anti-SS-B and ACL in the study group were higher than those in the control group(P<0.05). The AUC of the combined diagnosis for the assessment of hematological disorders in SS patients was higher than that of the individual diagnosis of each index (P<0.05).The positive rate of anti-SS-A in patients with anemia and WBC reduction was higher than that in patients with reduced PLT(P<0.05). The positive rate of anti-SS-B in patients with reduced WBC was higher than that in patients with anemia and PLT reduction(P<0.05)， and the positive rate of ACL in patients with reduced PLT was higher than that of patients with anemia and WBC reduction(P<0.05).The positive rate of ACL in patients with single-line damage was lower than that of patients with multi-line damage(P>0.05). Conclusion：The positive rates of anti-SS-A， anti-SS-B and ACL in patients with SS complicated with hematological disorders are higher， and patients with ≥2 positive items are more likely to develop hematological disorders， and patients with positive ACL have higher risk of multi-line damage.

Key words: font-size:medium, ">Sjogren′s syndrome；Hematological disorders；Antinuclear antibody spectrum； Anticardiolipin antibody

中图分类号:

安沛欣, 赵婵媛. 干燥综合征患者血液系统损害与抗核抗体谱、抗心磷脂抗体的相关性分析#br#[J]. 中国医药导刊, 2023, 25(1): 56-60.

AN Peixin, ZHAO Chanyuan. Correlation of Hematological Disorders with Antinuclear Antibody Spectrum and Anticardiolipin Antibodies in Patients with Sjogren′s Syndrome[J]. CHINESE JOURNAL OF MEDICINAL GUIDE, 2023, 25(1): 56-60.

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