中医定向透药疗法对精神分裂症合并骨质疏松症患者的临床疗效

摘要/Abstract

摘要： 目的：探讨中医定向透药疗法对精神分裂症合并骨质疏松症患者的临床疗效。方法：选取2019年1月至2021年9月我中心住院的120例精神分裂症合并骨质疏松症患者作为研究对象，按照配对分组法分为实验组和对照组，每组各60例。对照组患者采用阿法骨化醇软胶囊治疗，实验组患者在对照组患者治疗的基础上采用补肾强骨方剂电极片敷贴透药治疗。观察两组患者临床疗效、数字疼痛分级法(NRS)疼痛评分、骨密度（BMD）水平及生活质量。结果：实验组患者治疗总有效率优于对照组（P＜0.05）。两组患者治疗前NRS评分及BMD水平差异均无统计学意义（P>0.05）。治疗第3周及第6周，两组患者NRS疼痛评分均降低（P＜0.05），BMD水平均升高（P＜0.05），且实验组患者NRS疼痛评分降低幅度和BMD水平升高幅度均更高（P＜0.05）。两组患者治疗前简明健康状况调查问卷（SF-36）评分无统计学意义（P＞0.05）；治疗后，实验组患者SF-36评分高于对照组（P＜0.05）。结论：精神分裂症合并骨质疏松症患者采用补肾强骨方剂电极片敷贴透药治疗可以提高临床治疗有效率，降低疼痛，提高骨密度，改善患者生活质量。

关键词: font-size:medium, ">精神分裂症；骨质疏松症；透药疗法；疼痛；骨密度

Abstract: Objective：To investigate the clinical efficacy of Chinese medicine directed drug penetration therapy on osteoporosis in patients with schizophrenia. Methods： From January 2019 to September 2021， 120 patients with schizophrenia and osteoporosis who hospitalized in our hospital were selected as the research objects， and were divided into the experimental group， and the control group with 60 cases in each group according to the paired grouping method. Alfacalcidol capsules was used in the control group， and the experimental group was treated with directional drug penetration therapy of bushenqianggu recipe on the base of treatment of the control group. The clinical efficacy， NRS pain score， BMD level and quality of life of the two groups of patients were observed. Results： The total clinical effective rate of the experimental group was better than that of the control group(P＜0.05). The NRS score and BMD level of patients of the two groups before treatment has no statistical diffierence(P>0.05). At the 3 rd and 6 th week of treatment， the NRS pain score decreased and BMD increased in both groups (P＜0.05)， and the NRS pain score decreased and BMD increased more significantly in the experimental group than that in the control group (P＜0.05). Before treatment， the SF-36 scores of the two groups of patients has no statistical diffierence (P＞0.05). After treatment， the SF-36 scores of life score of the experimental group was higher than those of the control group (P<0.05). Conclusion： Directional drug penetration therapy of bushenqianggu recipe for patients with schizophrenia and osteoporosis can improve the clinical efficiency， reduce pain， increase bone density， and improve the quality of life of patients.

Key words: font-size:medium, ">Schizophrenia； Osteoporosis； Drug penetration therapy； Pain； Bone density

中图分类号:

高凤, 高存友, 沈静霞, 班春霞. 中医定向透药疗法对精神分裂症合并骨质疏松症患者的临床疗效[J]. 中国医药导刊, 2023, 25(1): 86-90.

GAO Feng, GAO Cunyou, SHEN Jingxia, BAN Chunxia. Clinical Efficacy of Directional Drug Penetration Therapy of Traditional ChineseMedicine on Osteoporosis in Patients with Schizophrenia[J]. CHINESE JOURNAL OF MEDICINAL GUIDE, 2023, 25(1): 86-90.

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