关键词: 慢性乙型肝炎, 还原型谷胱甘肽, 肝纤维化, 氧化应激, 肝功能

Abstract: Objective：To explore the clinical efficacy and mechanism of reduced glutathione adjuvant therapy for chronic hepatitis B (CHB) liver fibrosis. Methods：A total of 98 CHB patients were selected as the research subjects from January 2020 to August 2021.They were divided into the study group and the routine group according to the random number table method， with 49 cases in each group. Patients of the routine group received routine treatment， and pationts of the study group received reduced glutathione therapy on the basis of the routine group. The curative effect， liver function indexes [total bilirubin (TBIL)， alanine aminotransferase (ALT)， aspartate aminotransferase (AST)]， liver fibrosis indexes [type IV collagen (IVC)， laminin (LN)， hyaluronic acid (HA)]， oxidative stress indicators [malondialdehyde (MDA)， superoxide dismutase (SOD)]， serum reactive oxygen species (ROS)， reduced nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) levels before and after treatment and adverse reactions during treatment were compared between the two groups. Results： The total effective rate of the study group was 93.88%， which was higher than that of the routine group (79.59%， P<0.05). After treatment， the serum levels of TBIL， AST， ALT， HA， IVC， LN， ROS， NOX4 of patients in both groups was lower than those before treatment， and the reductions of the above indexes of the study group were all greater than those of the routine group(P<0.05). After treatment， the MDA level in the study group was lower than that of the conventional group， and the SOD level of patients in the study group was higher than that in the routine group (P＜0.05). No obvious adverse reactions occurred in both groups during the treatment. Conclusion：Reduced glutathione is effective in adjuvant treatment of CHB liver fibrosis patients， which can improve liver function and control liver fibrosis process by reducing NOX4 expression and ROS-mediated oxidative stress response， and it is with high safety.

Key words: Chronic hepatitis B, Reduced glutathione, Liver fibrosis, Oxidative stress, Liver function