关键词: font-size:medium, ">急性后循环脑梗死；阿替普酶；依达拉奉右莰醇；疗效；神经功能

Abstract: Objective：To investigate the efficacy of alteplase thrombolysis combined with edaravone dexborneol in the treatment of acute posterior circulation cerebral infarction and to analyze its effect on neurological function-related factors. Methods：105 patients with acute posterior circulation cerebral infarction admitted to our hospital from April 2020 to June 2022 were selected for the study and were divided into the single group(n=52) and the combined group(n=53) according to the random number table method. The single group was treated with alteplase thrombolysis and the combined group was treated with alteplase thrombolysis + edaravone dexborneol. The clinical efficacy and cerebral perfusion indexes [peak flow velocity(Vp)， mean flow velocity(Vm)， cerebrovascular resistance(CVR)， pulsatility index(PI)]， oxidative stress indexes [glutathione peroxidase(GSH-Px)， superoxide dismutase(SOD)， malondialdehyde(MDA)]， neurological function-related factors [neuron-specific enolase(NSE)， central nervous system specific protein(S100-β)] levels of the two groups of patients were compared. The degree of neurological deficits and the daily living ability were compared and analyzed between the two groups of patients. Results：The total effective rate of the combined group was 96.23%， which was higher than that of the single group 84.62%(P<0.05). The level of Vp， Vm and CVR were higher in the combined group than those in the single group and the level of PI was lower than that in the single group after treatment(P<0.05). The GSH-Px and SOD levels in the combined group were higher than those in the single group and the MDA， NSE and S100-β levels were lower than those in the single group after treatment(P<0.05). The combined group after treatment NIHSS score was lower than that of the single group， and the BI score was higher than that of the single group(P<0.05). Conclusion：The efficacy of alteplase thrombolysis combined with edaravone dexborneol in the treatment of patients with acute posterior circulation cerebral infarction is definite， which can improve their cerebral blood perfusion， reduce oxidative stress， promote the improvement of neurological function and enhance their daily living ability.

Key words: font-size:medium, ">Acute posterior circulation cerebral infarction； Alteplase； Edaravone dexborneol； Efficacy； Neurological function