关键词: font-size:medium, ">牡丹皮配方颗粒；没食子酸；儿茶素；芍药苷；丹皮酚；生产工艺

Abstract: Objective：To establish a method for simultaneous determination of four index components(gallic acid，Catechin，Paeoniflorin，Paeonol) in Cortex moutan formula granules， and analyze the influence of different production processes on the content of index components. Methods：Agilent C18 column(250 mm×4.6 mm，5 μm) was used.The mobile phase was acetonitrile-0.2% phosphoric acid solution with gradient elution at a flow rate of 1.0 mL·min-1.The detection wavelength was 230 nm.The content of the four index components in the production process was monitored. Results：Good linearity(r=0.9995-1.0000) was observed in the standard curves of gallic acid， Catechin paconiflorin and paeonol in the ranges of 1.07-107.34 μg·mL-1，1.08-108.12 μg·mL-1，1.01-101.14 μg·mL-1，1.04-104.24 μg·mL-1， respective. Different production process has significant influence on the content of catechin and paeonol. Conclusion：The method is rapid，simple and accurate and can qnickly and accurately determine the contert of four index components in the proudction process， which provides a basis for the quality control of cortex moutan formula granules.

Key words: font-size:medium, ">Cortex Moutan formula granules； Gallic acid； Catechin； Paconiflorin； Paeonol； Production process