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中国医药导刊 ›› 2023, Vol. 25 ›› Issue (4): 420-424.

• 中医中药 • 上一篇    下一篇

瓜蒌薤白半夏汤治疗稳定型心绞痛的疗效观察

吴甜1, 彭筱平2*   

  1. 1.湖南中医药大学, 湖南 长沙 410208;
    2.湖南中医药高等专科学校附属第一医院(湖南省直中医医院), 湖南 株洲 412000
  • 收稿日期:2023-05-10 修回日期:2023-05-08 出版日期:2023-04-28 发布日期:2023-04-28

Effects of Gualou Xiebai Banxia Decoction on Stable Angina Pectoris

  1. 1.Hunan University of Traditional Chinese Medicine, Hunan Changsha 410208, China;
    2.First Affiliated Hospital of Hunan Traditional Chinese Medicine College(Hunan Province Directly
         Affiliated TCM Hospital), Hunan Zhuzhou 412000, China
  • Received:2023-05-10 Revised:2023-05-08 Online:2023-04-28 Published:2023-04-28

摘要: 目的: 观察瓜蒌薤白半夏汤治疗冠心病稳定型心绞痛痰浊闭阻证的临床疗效。方法:收集我院60例稳定型心绞痛患者,根据随机数字表法分为对照组和治疗组,每组各30例。其中对照组患者予以西医综合治疗,治疗组患者在对照组治疗的基础上予以瓜蒌薤白半夏汤治疗,共治疗4周。观察治疗前后两组患者西雅图心绞痛量表评分、中医证候积分、血脂、单核细胞计数与HDL-C比值(MHR)、C反应蛋白(CRP)水平及血液流变学指标。结果:治疗后,治疗组患者西雅图心绞痛量表得分较对照组高(P<0.05),中医证候积分较对照组低(P<0.05);治疗组患者TC、TG、LDL-C水平均较对照组低,HDL-C水平较对照组高(P<0.05)。治疗组患者MHR、CRP水平较对照组低(P<0.05)。治疗组患者纤维蛋白原、血浆黏度及全血黏度水平较对照组低(P<0.05)。结论:对于痰浊闭阻型稳定型心绞痛患者,联合瓜蒌薤白半夏汤治疗有助于调节患者血脂代谢、减轻炎症反应、改善血液流变学水平,改善症状,提高临床疗效。

关键词: font-size:medium, ">稳定型心绞痛;瓜蒌薤白半夏汤;血脂;炎症因子;血液流变学

Abstract: Objective:To investigate the clinical effect of gualou xiebai banxia decoction on patients with stable angina pectoris of coronary heart disease with the syndrome of phlegm obstruction. Methods:60 stable angina pectoris patients with the syndrome of phlegm obstruction were selected and divided into the control group and the treatment group according to random number table. The control group was treated with western medicine and the treatment group was treated with gualou xiebai banxia decoction on the basis of the control group. Both groups were treated for a period of 4 weeks. The SAQ score, TCM syndrome score, blood lipid, MHR, CRP level and hemorheology index of the two groups of patients were observed before and after treatment. Results:After treatment, the SAQ scores of patients in the treatment group were higher than those in the control group, the scores of TCM syndrome were lower than the control group, the levels of TC, TG, LDL-C were lower than those in the control group, and the level of HDL-C was higher than that in the control group (P<0.05) . The levels of MHR and CRP of patients in the treatment group were lower than those in the control group(P<0.05). The levels of fibrinogen, plasma viscosity and whole blood viscosity of patients in the treatment group were lower than those in the control group (P<0.05). Conclusion:For patients with stable angina pectoris with the syndrome of phlegm obstruction, the treatment of conventional western medicine combined with gualou xiebai banxia decoction can help regulate blood lipid metabolism, reduce inflammatory reaction, improve hemorheology level and symptoms, improve the clinical efficacy.

Key words: font-size:medium, ">Stable angina pectoris;Gualou xiebai banxia decoction; Blood lipids;Inflammatory factors;Hemorheology

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