关键词: font-size:medium, ">ApoE；基因多态性；阿托伐他汀；畲族；高脂血症

Abstract: Objective：To investigate the ApoE gene polymorphisms of She nationality population， and the correlation between ApoE genetype and the cholesterol-lowering effect of atorvastatin calcium in hyperlipidemia patients of She nationality in eastern Fujian. Methods：The point-of-care testing system of drug-related genes was adopted to detect the ApoE gene polymorphisms of 50 health Han nationality people and 50 health She nationality people. 40 hyperlipidemia patients of Han nationality and 40 hyperlipidemia patients of She nationality received atorvastatin calcium at a oral dose of 20 mg·d-1. The lipid-lowering efficacy was evaluated through detecting serum low-density lipoprotein cholesterol (LDL-C) level before and 8 weeks after the treatment. Results：The gene distribution of ApoE gene was 8.0%， 66.0%，24.0% and 1.0% respectively for E2/E3， E3/E3，E3/E4 and E4/E4 group in 50 health Han nationality people. The gene distribution of ApoE gene was 10.0%， 86.0%，4.0%and 0% respectively for E2/E3， E3/E3， E3/E4 and E4/E4 group in 50 health She nationality people. The frequencies of E3， E4 allele gene and E3/E3， E3/E4 genotype in two nationalities showed statistical differences (P<0.05). After receiving atorvastatin for 8 weeks， the decreased LDL-C levels showed statistical differences (P<0.05) among E3/E3 and E3/E4+E4/E4 groups in two nationalities. Conclusion：The frequencies of E4 allele gene and E3/E4 genotype in She nationality in eastern Fujian is less than the frequencies in Han nationality. The gene polymorphism of ApoE is correlated with efficacy of atorvastatin calcium in hyperlipidemia patients of She nationality. The lipid-lowering efficacy of E4 gene carrier is poor.
 
    

Key words: font-size:medium, ">ApoE； Gene polymorphism；Atorvastatin；She nationality； Hyperlipidemia