血清B细胞活化因子水平与小儿川崎病冠脉损害的相关性和诊断价值

摘要/Abstract

摘要： 目的：探讨血清B细胞活化因子(sBAFF)水平与小儿川崎病冠状动脉(以下简称“冠脉”)损害的关系。方法：选择我院2020年1月至2022年7月接诊的120例川崎病患儿作为观察组，另选同期的120例健康体检儿作为对照组，比较两组儿童的sBAFF水平。根据是否合并冠脉损害，将观察组患儿分为冠脉损害组和非冠脉损害组；使用双抗体夹心酶联免疫吸附测定法检测sBAFF水平，比较观察组与对照组、冠脉损害组与非冠脉损害组sBAFF水平，使用Pearson相关性分析川崎病患儿sBAFF水平与白细胞计数(WBC)、血小板计数(PLT)、C反应蛋白(CRP)、红细胞沉降率(ESR)的关系，通过受试者工作特征曲线(ROC)下面积(AUC)评价sBAFF对小儿川崎病冠脉损害的诊断效能。结果：观察组患儿sBAFF水平高于对照组(P<0.05)；观察组患儿CRP、WBC、PLT、ESR表达水平均高于对照组(P<0.05)。在120例川崎病患儿中，继发冠脉损害31例，占25.83%；其中冠脉损害组sBAFF水平高于非冠脉损害组(P<0.05)。经Pearson相关性分析，川崎病患儿sBAFF水平与CRP、WBC、PLT、ESR水平均呈正相关(r值分别为0.356、0.415、0.482、0.563，P值均为0.000)；经ROC曲线分析，sBAFF预测川崎病患儿继发冠脉损害的AUC为0.915，大于CRP、WBC、PLT和ESR的AUC(P<0.05)。结论：sBAFF可能参与小儿川崎病的发生、发展，其血清水平有助于预测川崎病患儿继发冠脉损害。

关键词: font-size:medium, ">川崎病；冠状动脉；B细胞活化因子

Abstract: Objective： To investigate the correlation between serum B-cell activating factor (sBAFF) level and coronary artery lesions (CAL) in children with Kawasaki disease. Methods： A total of 120 children with Kawasaki disease admitted in our hospital from January 2020 to July 2022 were selected as the observation group， and 120 healthy children in the same period were selected as the control group. The sBAFF level of the two groups of children was compared. According to whether had CAL， the children in the observation group were divided into the CAL group and the non-CAL group. The sBAFF level was detected by double-antibody sandwich enzyme-linked immunosorbent assay， and the sBAFF level was compared between the observation group and the control group， and between the CAL group and the non-CAL group. Pearson correlation was used to analyze the correlation between sBAFF level and the levels of white blood cell count(WBC)，platelet count(PLT) and C-reactive protein(CRP) in children with Kawasaki disease. The diagnostic efficacy of sBAFF on CAL in children with Kawasaki disease was evaluated by area under the ROC curve(AUC). Results： The sBAFF level in the observation group was higher than that in the control group(P<0.05). The expression levels of CRP，WBC，PLT and ESR in the observation group were higher than those in the control group(P<0.05). In 120 children with Kawasaki disease， 31 cases (25.83%) suffered secondary CAL. The sBAFF level in the CAL group was higher than that in the non-CAL group (P<0.05). By Pearson correlation analysis， the level of sBAFF was positively correlated with the levels of CRP， WBC， PLT and ESR in children with Kawasaki disease(r values were 0.356， 0.415， 0.482 and 0.563， P values were all 0.000). According to ROC curve analysis， the AUC of sBAFF in prediction secondary CAL in children with Kawasaki disease was 0.915， which was greater than that of CRP，WBC，PLT and ESR(P<0.05). Conclusion： sBAFF may be involved in the occurrence and development of Kawasaki disease in children， and the serum level of sBAFF is helpful to predict the secondary CAL in children with Kawasaki disease.

Key words: font-size:medium, ">Kawasaki disease；Coronary artery；B cell activating factor

中图分类号:

雷红梅, 周占强. 血清B细胞活化因子水平与小儿川崎病冠脉损害的相关性和诊断价值[J]. 中国医药导刊, 2023, 25(5): 528-532.

LEI Hongmei, ZHOU Zhanqiang. Correlation between Serum B-cell Activating Factor Level and Coronary Artery Lesions in Children with Kawasaki Disease and Its Diagnostic Value[J]. CHINESE JOURNAL OF MEDICINAL GUIDE, 2023, 25(5): 528-532.

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