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中国医药导刊 ›› 2024, Vol. 26 ›› Issue (11): 1115-1120.

• 研究进展 • 上一篇    下一篇

中药皂苷抗抑郁机制研究进展

张格1, 吴民民1, 朱路文2*   

  1. 1.黑龙江中医药大学研究生院,黑龙江 哈尔滨 150040; 2.黑龙江中医药大学附属第二医院康复中心,黑龙江省脑功能与神经康复重点实验室,黑龙江 哈尔滨 150001
  • 收稿日期:2024-11-01 修回日期:2024-11-27 出版日期:2024-11-28 发布日期:2024-11-28
  • 基金资助:
    国家自然科学基金项目(82174477)

Research Progress on Antidepressant Mechanism of Saponins

  1. 1.Graduate School of Heilongjiang University of Traditional Chinese Medicine Heilongjiang Harbin 150040, China
    2.Rehabilitation Center the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine Heilongjiang Provincial
    Key Laboratory of Brain Function and Neurorehabilitation Heilongjiang Harbin 150001, China
  • Received:2024-11-01 Revised:2024-11-27 Online:2024-11-28 Published:2024-11-28

摘要:

抑郁症是一种严重限制心理社会功能和降低生活质量的常见疾病,影响全球3.5亿人。其病因错综复杂,发病机制主要与神经递质、炎症反应、神经可塑性、肠道菌群及细胞凋亡密切相关,这些生物学因素相互作用,导致抑郁症状进一步加重。目前临床应用的抗抑郁药存在诸多不良反应,而中药治疗抑郁症的作用逐渐得到了重视。临床和动物实验研究已经验证了中药在抑郁症的预防与治疗方面的有效性和安全性,其能显著改善患者抑郁症状,且毒副作用少。然而,中药皂苷类成分治疗抑郁症的具体作用机制尚未完全阐明。现代药理学研究证实,中药皂苷类成分(如人参皂苷、柴胡皂苷、绞股蓝皂苷等)可通过增加单胺类递质含量、抑制炎症反应、促进神经营养因子和神经元生长、重塑肠道菌群结构等,充分发挥抗抑郁作用。因此,本研究从以上方面探讨中药皂苷对抑郁症的治疗作用。未来需要进一步深入研究中药皂苷抗抑郁的作用机制,为开发皂苷类化合物作为抗抑郁药提供依据。

关键词: 中药, 皂苷, 抗抑郁, 作用机制

Abstract:

Depression is a common disease that severely limits psychosocial functioning and reduces quality of life affecting 350 million people worldwide. The etiology of depression is complex and its pathogenesis is closely related to neurotransmitters inflammatory response neuroplasticity intestinal flora and apoptosis. These biological factors interact with each other to further aggravate depression symptoms. Antidepressants currently used in clinic have a lot of adverse reactions and the effect of traditional Chinese medicine in treating depression has gradually been valued. Clinical and animal studies have verified the effectiveness and safety of traditional Chinese medicine in the prevention and treatment of depression specifically traditional Chinese medicine can significantly improve the symptoms of depression in patients and with few toxic side effects. However the specific mechanism of Saponins in Chinese medicine in the treatment of depression has not been fully clarified. According to modern pharmacological studies Saponins in Chinese medicine such as ginsenoside saikosaponin gypenosides etc. can fully exert the antidepressant effect by increasing the content of monoamine transmitters inhibiting inflammatory reaction promoting neurotrophic factors and neuron growth remodeling intestinal flora structure etc. Therefore this paper will discuss the therapeutic effect of saponins in Chinese medicine on depression from the above aspects. In the future it is necessary to further study the anti-depression mechanism of saponins and provide basis for the development of saponins as antidepressants.


Key words:  , Traditional Chinese medicine , Saponin , Antidepression , Mechanism

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