关键词: 血清, 糖类抗原19-9, 高迁移率族蛋白1, 尿调节素, 急性胆囊炎

Abstract:

Objective： To investigate the correlation between serum carbohydrate antigen 19-9 （CA19-9）， high mobility group box 1 protein （HMGB1）， uromodulin （UMOD） levels and the severity of acute cholecystitis （AC）.Methods： A total of 99 patients with AC treated in our hospital from January 2022 to August 2023 were included in the study group， and 99 healthy subjects were included in the control group during the same period. The serum CA19-9， HMGB1 and UMOD levels were compared between the two groups and patients with different degrees of AC at the time of admission， and their correlation with the degree of disease and the efficacy of the combined test were analyzed.Results： The serum levels of CA19-9 and HMGB1 of patients in the study group were higher than those in the control group， and the serum level of UMOD was lower than that in the control group （P < 0.05）. The levels of serum CA19-9 and HMGB1 of patients with different disease degrees were compared： mild patients < moderate patients < severe patients. Serum UMOD levels were compared： severe patients < moderate patients < mild patients （P < 0.05）. The levels of serum CA19-9 and HMGB1 were positively correlated with the severity of AC， while the levels of UMOD were negatively correlated with the severity of AC （P < 0.05）. With moderate AC patients as positive samples and mild AC patients as negative samples， the AUC of serum CA19-9， HMGB1 and UMOD combined detection was 0.824 （P < 0.05）. With patients with severe AC as positive samples and patients with moderate AC as negative samples， the AUC of the combined detection of serum CA19-9， HMGB1 and UMOD levels was 0.837 （P < 0.05）.Conclusion： Serum CA19-9， HMGB1， UMOD levels are closely related to the degree of disease in AC patients， and can be used as a reference index to judge the severity of AC and make diagnosis and treatment plan.

Key words:  ,  , Serum； , Carbohydrate antigen 19-9； , High mobility group box 1 protein； , Uromodulin； , Acute cholecystitis