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中国医药导刊 ›› 2024, Vol. 26 ›› Issue (2): 149-154.

• 研究进展 • 上一篇    下一篇

结直肠癌炎症微环境及中药治疗的研究进展

赵闫美黛1, 南鹏1, 郝淑兰2*, 刘丽坤2, 薛美平2, 李娟2   

  1. 1.山西中医药大学,山西 太原 030024;
    2.山西省中医院,山西 太原 030012
  • 收稿日期:2023-05-25 修回日期:2023-11-08 出版日期:2024-02-28 发布日期:2024-02-28
  • 基金资助:
    山西省医学重点科研项目(2022XM10);第二批国家中医临床研究基地建设项目(国中医药科技函[2018]131号);山西省医学重大科技攻关专项(2020XM04);中央引导地方科技发展资金项目(YDZJSX20231C020);山西省卫生健康委科研课题(2023092)

Research Progress on Inflammatory Microenvironment and Traditional Chinese Medicine Treatment of Colorectal Cancer

  1. 1.Shanxi University of Chinese Medicine Shanxi Taiyuan 030024, China
    2.Shanxi Traditional Chinese Medicine Hospital Shanxi Taiyuan 030012, China
  • Received:2023-05-25 Revised:2023-11-08 Online:2024-02-28 Published:2024-02-28

摘要:

结直肠癌是常见的胃肠道肿瘤,发病过程常伴随着炎症反应。炎症的持续为肿瘤生长提供适宜环境,免疫细胞、炎性因子、基质细胞和细胞外基质等组成炎症微环境,导致免疫应答与免疫抑制失衡,肿瘤细胞无限增殖,细胞凋亡被抑制,新生血管增加。炎性通路相关的STAT3NF-κB信号分子,炎性因子TNF-αIL-IL-6,这些关键分子相互作用,与肿瘤的侵袭和转移密切相关。靶向介导炎症的关键细胞和因子成为肿瘤新的治疗策略。中药具有多组分多靶点的特征,多种临床常用中药复方的分子机制表现为调节微环境炎性因子水平,抑制促肿瘤的信号通路转导,缓解肠黏膜炎性损伤,改善机体免疫功能。本研究通过对炎症微环境及中药抗癌机制的分析,以期为结直肠癌中药治疗思路提供参考。


关键词: 结直肠癌, 炎症微环境, 中药

Abstract:

Colorectal cancer is a common gastrointestinal tumor and its pathogenesis is often accompanied by inflammation. The persistence of inflammation provides a suitable environment for tumor growth. The inflammatory microenvironment mainly consists of immune cells inflammatory factors stromal cells and extracellular matrix which leads to the imbalance of immune response and immunosuppression infinite proliferation of tumor cells inhibition of apoptosis and increase of new blood vessels. STAT3 and NF-κB signaling molecules related to inflammatory pathways and inflammatory factors TNF-α IL-1β and IL-6 these key molecular interactions are closely related to tumor invasion and metastasis. Targeting key cells and factors mediating inflammation has become a new therapeutic strategy for cancer. Traditional Chinese medicine is characterized by multiple components and multiple targets. The molecular mechanism of many commonly used tradition Chinese compound medicine in clinical practice is to regulate the level of microenvironmental inflammatory factors inhibit the signaling pathway of tumor promotion alleviate the inflammatory damage of intestinal mucosa and improve the body's immune function. Through the analysis of inflammation microenvironment and anti-cancer mechanism of traditional Chinese medicine we hope to provide reference for the treatment of colorectal cancer with traditional Chinese medicine.

Key words:  , Colorectal cancer; Inflammatory microenvironment; Traditional Chinese medicine

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