关键词: 降钙素原, 血清淀粉样蛋白A, 细菌培养, 细菌性肺炎, 病毒性肺炎

Abstract:

Objective： To explore the clinical significance of serum procalcitonin （PCT） and amyloid A （SAA） determination combined with sputum bacterial culture in the diagnosis of bacterial pneumonia.Methods： The clinical data of 120 patients with pulmonary infection admitted to our hospital from January 2022 to June 2023 were retrospectively analyzed. The patients were grouped according to the final diagnosis results， including 60 cases in the viral pneumonia group and 60 cases in the bacterial pneumonia group. The results of serological inflammatory indicators ［PCT， SAA， C-reactive protein （CRP）］ and bacterial culture results of sputum specimen of the two groups of patients were compared.The independent influencing factors for the differential diagnosis of bacterial pneumonia and viral pneumonia，and the predictive value of each factor in the diagnosis of bacterial pneumonia were analyzed.Results： There was no statistical difference in serum CRP levels between the two groups of patients（P>0.05）. The levels of serum PCT and SAA of patients in the bacterial pneumonia group were higher than those in the viral pneumonia group （P<0.05）. Multivariate Logistic analysis showed that serum PCT， SAA levels and bacterial culture results of sputum specimen were independent influencing factors in the differential diagnosis of bacterial pneumonia and viral pneumonia （P<0.05）. PCT， SAA， bacterial culture results of sputum specimen and P value of Logistic regression model were used to predict bacterial pneumonia， and the Yoden index was 41.67%， 35.00%， 78.33% and 81.67%， respectively.Conclusion： Serum PCT and SAA levels have a relatively good significance in the differential diagnosis of bacterial pneumonia and viral pneumonia， and the combination of PCT and SAA determination and sputum bacterial culture can further improve the prediction and diagnosis value for bacterial pneumonia.

Key words: Procalcitonin； , Serum amyloid A； , Bacterial culture； , Bacterial pneumonia； , Viral pneumonia