关键词: 甲胎蛋白, 癌胚抗原, 神经元特异性烯醇化酶, 非小细胞肺癌, 血清肿瘤标志物

Abstract:

Objective： To investigate the application value of serum alpha-fetoprotein （AFP）， carcinoembryonic antigen （CEA）， neuron-specific enolase （NSE）， and soluble cytokeratin 19 fragment （CYFRA211） in the diagnosis of non-small cell lung cancer （NSCLC）.Methods： The clinical data of 80 patients with NSCLC and 80 patients with benign lung lesions admitted to our hospital from January 2021 to December 2022 were retrospectively analyzed. The quantitative results of serum tumor markers and the positive rate of serum tumor markers were compared between the two groups. The efficacy of each serum tumor markers in diagnosing NSCLC was compared. The independent factors influencing the diagnosis of NSCLC by serum tumor markers were analyzed.Results： The serum CEA， NSE and CYFRA211 levels of patients in the NSCLC group were higher than those of the benign lung lesion group （P<0.05）. There was no statistical difference in the positive rate of AFP between the two groups （P>0.05）. The positive rates of CEA， NSE and CYFRA211 in the NSCLC group were higher than those of the benign lung lesion group （P<0.05）. The diagnostic sensitivity， negative predictive value and Kappa value of CEA， NSE and CYFRA211 were higher than those of AFP when each serum tumor marker was used alone in the diagnosis of NSCLC （P<0.05）. Multivariate Logistic analysis showed that CEA， NSE and CYFRA211 positivity were independent risk factors for diagnosing NSCLC by serum tumor markers （P<0.05）.Conclusion： Serum CEA， NSE and CYFRA211 have good diagnostic values for NSCLC.

Key words: Alpha-fetoprotein； , Carcinoembryonic antigen； , Neuron-specific enolase； , Non-small cell lung cancer； , Serum tumor marker