关键词: 头皮针, 重复经颅磁刺激, 帕金森病, 抑郁, 脑电图, 白细胞介素-6, 神经元特异性烯醇化酶

Abstract:

Objective： To explore the clinical efficacy of scalp acupuncture combined with repetitive transcranial magnetic stimulation （rTMS） in the treatment of Parkinson's disease with depression （PDD）， and to explore its effects on electroencephalogram （EEG） and serum interleukin-6 （IL-6）， cortisol （Cor）， neuron-specific enolase （NSE） levels.Methods： A total of 138 PDD patients admitted to the neurology department of integrated traditional Chinese and western medicine in our hospital were selected as the research objects， and were divided into the observation group and the control group according to random number table method， with 69 cases in each group. The control group was treated with conventional western medicine， and the observation group was treated with scalp acupuncture and rTMS on the basis of the control group for 12 consecutive weeks. The Unified Parkinson's Disease Rating Scale （UPDRS）， the 24-item Hamilton Depression Scale （HAMD-24）， the Pittsburgh Sleep Quality Index （PSQI）， and the 39-item Parkinson's Disease Questionnaire （PDQ-39） of the patients were assessed before treatment and after 4， 8， and 12 weeks of treatment. EEG and serum IL-6， Cor， NSE were detected before and after the treatment. The adverse reactions of the two groups of patients were observed during the treatment.Results： At the 8 and 12 weeks of treatment， the scores of UPDRS-Ⅰ， UPDRS-Ⅱ， UPDRS-Ⅲ， UPDRS-Ⅳ， HAMD-24， PSQI， and PDQ-39 of patients in the observation group were lower than those of the control group （P<0.05）. After treatment， the abnormal EEG activities improved in both groups （P<0.05）， and the EEG of patients in the observation group （P<0.05） was better than that in the control group （P<0.05）. After treatment， the serum IL-6， Cor and NSE levels of patients in both groups decreased （P<0.05）， and the serum IL-6， Cor and NSE levels of patients in the observation group were lower than those in the control group （P<0.05）. The incidence of adverse reactions in the observation group was 15.94%， which had no statistical difference compared with 20.29% in the control group （P>0.05）.Conclusion： Scalp acupuncture combined with rTMS in the treatment of PDD can effectively improve the EEG and serum IL-6， Cor， and NSE levels， reduce depression， improve the quality of sleep and life， and has good safety.

Key words: Scalp acupuncture； , Repetitive transcranial magnetic stimulation； , Parkinson's disease； , Depression； , Electroencephalogram； , Interleukin-6； , Neuron-specific enolase