关键词: 加味四妙散, 中草药外敷, 秋水仙碱, 痛风性关节炎, Meta分析

Abstract:

Objective： The objective of this study is comprehensively assess the efficacy and safety advantages of Jiawei Simiao powder combined with external Chinese herbal medicine application compared using colchicine alone in the treatment of acute gouty arthritis.Methods： The PubMed， CNKI （China National Knowledge Infrastructure）， VIP （VIP Database）， Wanfang （Wanfang Database）， and CBM （Chinese Biomedical Literature Database） were systematically searched to identify clinical randomized controlled trials of Jiawei Simiao powder combined with Chinese herbal medicince external application for the treatment of acute gouty arthritis. The time range was from January 2000 to October 2024. The risk of bias of the collected literature data was evaluated according to the guidelines of the Cochrane Handbook， and a Meta-analysis of efficacy and safety was conducted using RevMan 5.4 software.Results： Among the 11 included literatures， a total of 1 014 subjects were involved. Through Meta-analysis： the total effective rate of Jiawei Simiao powder combined with external application of Chinese herbal medicine was superior to that of using colchicine alone， and the difference was statistically significant （RR = 1.13， 95% CI = 1.08 to 1.18， P  0.000 01）； the effects of reducing VAS score （MD = -1.10， 95% CI = -1.25 to -0.96）， UA （MD = -98.73， 95% CI = -117.66 to -79.80）， ESR （MD = -6.14， 95% CI = -8.00 to -4.28）， and CRP （MD = -5.79， 95% CI = -10.48 to -1.11） were better than those of using colchicine alone （P  0.05）； the incidence of adverse reactions in patients was lower than that of using colchicine alone （RR = 0.04， 95% CI = 0.02 to 0.12， P  0.000 01）.Conclusion： The efficacy and safety of Jiawei Simiao powder combined with external application of Chinese herbal medicine in the treatment of acute gouty arthritis are superior to colchicine. More large-sample， multi-center， and high-quality clinical RCT studies are still needed to confirm the above conclusions.

Key words:  , Jiawei Simiao powder； , Chinese herbal medicine external application； , Colchicine； , Gouty arthritis； , Meta-analysis