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中国医药导刊 ›› 2026, Vol. 28 ›› Issue (1): 78-78-86.doi: magtech.2025.07.14-00002

• 研究进展 • 上一篇    下一篇

中医药防治宫颈癌的研究进展

梁美林1, 张丽娟2*   

  1. 1.山东中医药大学第一临床医学院,山东 济南 250014;

    2.山东中医药大学,山东 济南 250014

  • 收稿日期:2025-07-14 修回日期:2025-09-07 接受日期:2025-11-15 出版日期:2026-01-28 发布日期:2026-02-11
  • 基金资助:
    山东省卫生健康委名老中医药专家王东梅传承工作室项目(鲁卫函〔2019〕92号)

Research Progress on the Prevention and Treatment of Cervical Cancer with Traditional Chinese Medicine

LIANG Meilin1, ZHANG Lijuan2*   

  1. 1.The First Clinical Medical College Shandong University of Traditional Chinese Medicine Shandong Jinan 250014, China
    2.Shandong University of Traditional Chinese Medicine Shandong Jinan 250014, China
  • Received:2025-07-14 Revised:2025-09-07 Accepted:2025-11-15 Online:2026-01-28 Published:2026-02-11

摘要:

宫颈癌(cervical cancerCC)作为女性常见恶性肿瘤,具有病程长、病情隐匿、传播途径广泛等特点,且恶性程度高、预后较差。西医主要采取手术切除病灶,辅以放疗、化疗等手段延缓疾病进展,降低CC患者病死率、复发率,在取得疗效的同时,常伴随骨髓抑制、胃肠道反应、下肢水肿等不良反应。中医药基于整体观念,具有多靶点、多通路的调控优势,在CC的防治中显示出独特价值。现有研究多集中于名医经验总结和临床观察,而对其作用机制的深入探讨相对不足。本研究系统综述中医药防治CC的作用机制,主要包括抑制细胞增殖、迁移与侵袭能力、诱导细胞凋亡、阻断细胞周期、调节免疫失衡、抑制血管生成等方面,并涉及磷脂肌醇-3-激酶(PI3K/蛋白激酶BAkt/哺乳动物雷帕霉素靶蛋白(mTOR)、Wnt/β连环蛋白(β-catenin)、丝裂原活化蛋白激酶(MAPK)等多条信号通路,旨在为中医药在未来对CC的临床治疗及实验研究提供有价值的指导与借鉴。


关键词:  , 宫颈癌;高危型人乳头瘤病毒;中医药;作用机制

Abstract:

Cervical cancer CC), as a common malignant tumor in women is characterized by a long course of disease concealed symptoms extensive transmission routes high degree of malignancy and poor prognosis.Western medicine mainly adopts surgical resection of lesions supplemented by radiotherapy chemotherapy and other means to delay disease progression and reduce the mortality and recurrence rate of CC patients. While achieving curative effect it is often accompanied by bone marrow suppression gastrointestinal reactions lower limb edema and other adverse reactions.Based on the holistic concept traditional Chinese medicine has the advantage of multi-target and multi-channel regulation which shows unique value in the prevention and treatment of CC.Most of the existing studies in this field focus on the experience summary and clinical observation of famous doctors but the in-depth study of their mechanism is relatively insufficient.This study systematically reviews the mechanism of traditional Chinese medicineTCMin preventing and treating CC mainly including inhibiting cell proliferation migration and invasion ability inducing cell apoptosis blocking cell cycle regulating immune imbalance and inhibiting angiogenesisetc.It also involves multiple signaling pathways such as phosphatidylinositol-3-kinase PI3K/protein kinase B Akt/mammalian target of rapamycinmTOR), Wnt/β-catenin and mitogen-activated protein kinase MAPK),aiming to provide valuable guidance and reference for the future clinical treatment and experimental research of TCM on CC.


Key words: Cervical cancer , High-risk human papilloma virus , Traditional Chinese medicine , Mechanism of action

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