Abstract: Objective：To explore the effects of misoprostol on serum retinol binding protein and coagulation function in puerperas with pregnancy induced hypertension. Methods： A total of 104 puerperas with pregnancy induced hypertension who were treated in obstetrics and gynecology department in our hospital from March 2018 to May 2019 were randomly divided into control group (n=52) and observation group (n=52). The control group received conventional oxytocin treatment， and the observation group was treated with misoprostol on that baisis. The changes in serum retinol binding protein (RBP) and coagulation function were observed in the two groups. The systolic blood， diastolic pressure， and postpartum hemorrhage(24 h) of the two groups were compared immediately after delivery and 24 hours after treatment. Results：The RBP level in the observation group was lower than that in the control group (P<0.01). After treatment， the systolic blood pressure， diastolic blood pressure， and postpartum hemorrhage in the observation group were all lower than those in the control group (P<0.01). After treatment， the coagulation indexes PT， TT， and APTT in the observation group were significantly lower than those in the control group， and the FIB increased more significantly (P<0.01). Conclusion：The application of misoprostol in the treatment of puerperas with pregnancy induced hypertension can regulate the blood coagulation system and RBP levels， and effectively reduce the risk of postpartum hemorrhage.