关键词: font-size:medium, ">噻托溴铵粉吸入剂；复方甲氧那明；慢性阻塞性肺疾病；深吸气量；不良反应

Abstract: Objective： To explore the clinical effect of tiotropium bromide inhalant combined with compound methoxyphenamine on COPD patients in stable period. Methods： 152 patients with COPD in stable period were randomly divided into the observation group(76 cases) and the control group(76 cases) from February 2018 to January 2020. Compound methoxyphenamine was used in the treatment of control group and tiotropium bromide inhalant was added in the treatment of observation group on the basis of the treatment of control-group. Before and after the treatment， the pulmonary ventilation index， six-minute walk distance (6MWD)， adverse reactions and effectiveness of the treatment were compared between the two groups. Results： After treatment， the indexes of lung ventilatory function such as IC， FVC and FEV1% in the two groups were higher than those before treatment， and the increase in the observation group was more obvious(P<0.05). 6MWD in the two groups was improved after treatment (P<0.05)， and the improvement in the observation group was more obvious (P<0.05). The incidence of complications in the observation group was 9.21%， which was lower than that in the control group (22.37%) (P<0.05). The effective rate of the observation group (93.42%) was higher than that of the control group (81.58%) (P<0.05). Conclusion： Tiotropium bromide inhalant combined with compound methoxyphenamine is effective in the treatment of COPD patients in stable stage. It can improve the pulmonary ventilation function， relieve the dyspnea symptoms and reduce the incidence of adverse reactions.

Key words: font-size:medium, ">Tiotropium bromide powder for inhalation； Compound methoxyphenamine； COPD； Inspiratory capacity； Adverse reactions