匹伐他汀联合曲美他嗪对老年不稳定型心绞痛合并2型糖尿病患者PCI术后血管内皮功能的影响

摘要/Abstract

摘要： 目的：探讨匹伐他汀联合曲美他嗪对老年不稳定型心绞痛合并2型糖尿病患者经皮冠脉介入治疗（PCI）术后疗效及对血管内皮功能的影响。方法：选择我院120例老年不稳定型心绞痛合并2型糖尿病患者，按随机数字表法分为对照组、观察组，每组各60例。对照组患者于PCI术前给予常规药物治疗（他汀类药物选用匹伐他汀每日2 mg 口服），观察组患者于对照组治疗基础上口服曲美他嗪20 mg每日3次，比较两组患者在治疗前后血脂、高敏C反应蛋白（hs-CRP）、内皮素（ET-1）及一氧化氮（NO）水平变化，并观察两组患者预后情况。结果：治疗后两组患者血管内皮功能指标NO水平较治疗前升高，ET-1、hs-CRP水平则下降，观察组较对照组变化更明显（P＜0.05）；两组患者经治疗后不良心血管事件发生率比较，差异无统计学意义（P>0.05）。结论：老年不稳定型心绞痛合并2型糖尿病患者PCI术前给予匹伐他汀联合曲美他嗪治疗可以更有效降低血清炎性因子水平，改善血管内皮功能，安全性较好。

关键词: font-size:medium, ">不稳定型心绞痛；2型糖尿病；匹伐他汀；曲美他嗪；高敏C反应蛋白；内皮功能

Abstract: Objective：To investigate the effect of pivastatin combined with trimetazidine in elderly patients with unstable angina pectoris and type 2 diabetes mellitus after percutaneous coronary intervention (PCI) and its effect on vascular endothelial function. Methods：120 elderly patients with unstable angina pectoris and type 2 diabetes in our hospital were randomly divided into the control group and the observation group, 60 cases in each group. The control group was given routine drug treatment before PCI (pitvastatin 2 mg/d was taken orally), and the observation group was given trimetazidine 20 mg 3 times /d on the basis of the control group. The changes of the level of blood lipid, high sensitive C-reactive protein (hs-CRP), endothelin (ET-1) and nitric oxide (NO) were compared before and after the treatment, and the prognosis of the two groups was observed. Results：After treatment, the vascular endothelial function index No level of the two groups increased, while ET-1 and hs-CRP level decreased. The change in the observation group was more obvious than those in the control group, and the difference was statistically significant(P<0.05). There was no significant difference in the incidence of adverse cardiovascular events between the two groups (P>0.05). Conclusion：Pivastatin combined with trimetazidine treatment in elderly patients with unstable angina pectoris and type 2 diabetes mellitus after PCI can effectively reduce the serum inflammatory factor levels and improve the vascular endothelial function.

Key words: Unstable angina, Type 2 diabetes, Pivastatin, Trimetazidine, High sensitive C-reactive protein, Endothelial function

中图分类号:

王要鑫, 刘洁云, 秦雷, 李勇, 孟照娜. 匹伐他汀联合曲美他嗪对老年不稳定型心绞痛合并2型糖尿病患者PCI术后血管内皮功能的影响[J]. 中国医药导刊, 2022, 24(2): 148-151.

WANG Yaoxin, LIU Jieyun, QIN Lei, LI Yong, MENG Zhaona. Effect of Pivastatin Combined with Trimetazidine on Vascular Endothelial Function in Elderly Patients with Unstable Angina Pectoris and Type 2 Diabetes Mellitus after PCI[J]. CHINESE JOURNAL OF MEDICINAL GUIDE, 2022, 24(2): 148-151.

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