关键词:  , 骨折延迟愈合；中医药治疗；数据挖掘；中药方剂；R软件分析

Abstract:

Objective： To investigate the efficacy of traditional Chinese medicine （TCM） prescriptions in the treatment of delayed fracture healing at our hospitial and to summarize the treatment patterns， providing new TCM diagnostic and treatment approaches for clinical practice.Methods： A retrospective case study method was used， to collect the clinical data of patients with delayed fracture healing were collected who met the inclusion criteria from the HIS system of our hospital. Data analysis was performed using R software， including frequency analysis， association rules， phi correlation analysis， and cluster analysis， to explore the prescription patterns and treatment ideas of TCM.Results： A total of 215 cases were included， with 179 types of drugs， 42 types of drug categories， 308 types of drug effects， and 566 types of diseases treated. The four properties （Qi） were mainly warm and neutral， the five flavors （Wei） were mainly sweet， bitter， and pungent， and the channels entered were mainly liver， kidney， and lung. There were 21 strong associated drug pairs， 262 core drugs， and 73 nodes with 806 edges in the drug co-occurrence network. Among these， "Drynaria， Eucommia， Pyrite， Epimedium， Rhizoma Cibotii， Ground Beetle， Os Draconis， Radix Dipsaci， Cortex Albizziae， Radix Astragali， Safflower" had the highest phi correlation. Four possible new prescription combinations were identified， including "Rhizoma Cibotii， Os Draconis， Pyrite， Eucommia， Radix Astragali， Epimedium， Ground Beethe" "Cortex Albizziae， Drynaria， Radix Achyranthis Bidentatae， Radix Dipsaci， Radix Angelicae Sinensis ， Rhizoma Chuanxiong， Safflower" "Caulis Sinomenii， Centipede， Earthworm， Cassia Twig， Puerariae Thomsonii Radix" and "Malt， hawthorn frvie， Coix Seed， Coastal Glehnia Root， Rhizoma Atractylodis Macrocephalae， Polygala root， Rhizoma Atractylodis， Spine Date Seed， Poria， Licorice， Nacre". Conclusion： The TCM prescriptions used at our hospital for the treatment of delayed fracture healing primarily focus on tonifying the liver and kidney and promoting tendon and bone healing. This study has formulted new prescription combinations for the treatment of delayed fracture healing， providing innovative ideas for future TCM treatment strategies.

Key words: Delayed fracture healing； , Traditional Chinese medicine treatment； , Data mining； , Chinese medicine prescriptions； , R software analysis