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中国医药导刊 ›› 2025, Vol. 27 ›› Issue (5): 437-441.

• 研究进展 • 上一篇    下一篇

基于脂质代谢重编程探讨中药防治肝细胞癌的研究进展

卢燕文1, 斯韬2*, 黄丽银3    

  1. 1.广西中医药大学研究生院,广西 南宁 530200;

    2.柳州市中医医院/柳州市壮医医院,广西 柳州 545001;

    3.桂林市中医医院,广西 桂林 541002
  • 收稿日期:2025-01-02 修回日期:2025-01-20 接受日期:2025-03-14 出版日期:2025-05-28 发布日期:2025-07-23
  • 基金资助:
    国家自然科学基金资助项目(82060856、82460958);广西中医药优秀人才研修项目(2023年)

Research Progress on Prevention and Treatment of Hepatocellular Carcinoma with Traditional Chinese Medicine Based on Reprogramming of Lipid Metabolism

LU Yanwen1, SI Tao2*, HUANG Liyin3   

  1. 1.Graduate School of Guangxi University of Traditional Chinese Medicine Guangxi Nanning 530200, China
    2.Liuzhou Traditional Chinese Medicine HospitalGuangxi Liuzhou 545001, China
    3.Guilin Traditional Chinese Medicine HospitalGuangxi Guilin 541002, China
  • Received:2025-01-02 Revised:2025-01-20 Accepted:2025-03-14 Online:2025-05-28 Published:2025-07-23

摘要:

肝细胞癌是我国高发病率、死亡率的恶性肿瘤之一,高度依赖不同的代谢途径来维持其生存、侵袭和转移。肝脏作为人体主要的代谢器官,在脂质代谢重编程中起着重要作用。了解肝癌脂质代谢重编程规律,以及如何通过调节脂质代谢以破坏肿瘤生长微环境,有助于更有针对性地治疗肝细胞癌。近年来,关于肝细胞癌脂质代谢重编程相关因子、通路及中药干预肝细胞癌发生发展的研究越来越多,本研究通过对近年来国内外关于肝细胞癌脂质代谢重编程及中药防治肝细胞癌作用机制的研究进展进行论述,以期为肝细胞癌的防治提供策略。


关键词:  , 肝细胞癌;脂质代谢重编程;中药

Abstract:

Hepatocellular carcinoma is one of the malignant tumors with high morbidity and mortality in China and is highly dependent on different metabolic pathways for its survival invasion and metastasis. As a major metabolic organ in the human body the liver plays an important role in lipid metabolic reprogramming. In-depth understanding of the lipid metabolism reprogramming rules of hepatocellular carcinoma and how to regulate hepatic lipid metabolism in order to disrupt the microenvironment of tumor growth can help to treat hepatocellular carcinoma in a more targeted manner. In recent years more and more studies have been conducted on the factors and pathways related to lipid metabolic reprogramming in hepatocellular carcinoma and the intervention of traditional Chinese medicine in the development of hepatocellular carcinoma. This sutdy discusses the research progress of lipid metabolic reprogramming in hepatocellular carcinoma and the mechanism of traditional Chinese medicine preventing and controlling hepatocellular carcinoma at home and abroad in recent years with the aim of providing strategies for the prevention and treatment of hepatocellular carcinoma.


Key words: Hepatocellular carcinoma , Lipid metabolic reprogramming , Traditional Chinese medicine

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