Abstract: 【Abstract】 objective to investigate the correlation between the interferon alpha 2 b hepatitis b with HBV - DNA Yin turn rate and the influence of TBIL, ALT.Methods randomly selected from May 2012 to May 2015 hepatitis b patients of our hospital 80 cases, according to the treatment of these children can be divided into two groups, namely group (n = 40) and the control group (n = 40).To the control group with small dose interferon alpha 2 b treatment, giving the team with high doses of interferon alpha 2 b treatment, then the two groups of children with TBIL, ALT and HBV - DNA often turn Yin situation, carried out a statistical analysis on the clinical curative effect and adverse reactions occur.Results the team can later on and treatment after treatment in children with TBIL, ALT often rate and HBV - DNA Yin turn rate were significantly higher than that of control group (P < 0.05), the treatment, the total effective rate was 90.0% (36/40) was significantly higher than the control group 65.0% (26/40) significantly increased (P < 0.05), ALT, leukopenia, thrombocytopenia rates were significantly higher than that of control group (P < 0.05), but the two groups of children with influenza-like symptoms, anxiety, depression incidence differences were not significant (P > 0.05).Conclusion high-dose small dose interferon alpha 2 b hepatitis b can be effectively increased with HBV - DNA Yin turn rate and TBIL, ALT often rate, worthy of promotion.