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埃索美拉唑三联疗法在不同年龄幽门螺杆菌相关性胃溃疡患者中的应用比较

翟红兵1,穆利萍1   

  1. 陕西省咸阳市中心医院消化科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-06-25

  • Received:1900-01-01 Revised:1900-01-01 Online:2016-06-25

摘要: 摘要】目的:分析和探讨埃索美拉唑三联疗法在不同年龄幽门螺杆菌相关性胃溃疡患者中的应用效果。方法:选择从2012年12月至2014年12月在本院进行治疗的年龄为17-59岁,幽门螺杆菌(Hp)阳性的溃疡患者94例,设为甲组;选择同期年龄为60-79岁,HP阳性的溃疡患者患者95例,设为乙组。全部患者先每天2次甲硝唑400mg,阿莫西林1000mg,埃索美拉唑20mg治疗,持续7d;然后每天1次埃索美拉唑20mg,持续21d。28d后观察两组的应用效果。结果:在临床症状方面,甲组治疗总有效率91.49%,乙组84.21%,比较差异具有统计学意义(P<0.05);在溃疡愈合方面,甲组治疗总有效率89.36%,乙组92.63%,比较差异不具有统计学意义(P>0.05)。在Hp根除率方面,甲组根除率88.30%,乙组90.53%,比较差异不具有统计学意义(P>0.05)。在不良反应方面,甲组恶心1例,无其他不良反应,发生率为1.06%;乙组恶心3例,头痛2例,食欲不振5例,发生率为10.53%。不良反应发生率比较差异具有统计学意义(P<0.05)。结论:

Abstract: Abstract] Objective: to analyze and evaluate the efficacy of esomeprazole triple therapy in the application effect of different age patients with Helicobacter pylori associated gastric ulcer. Methods: from December 2012 to December 2014 in our hospital for treatment of aged 17-59 of Helicobacter pylori (Hp) positive patients with ulcer 94 cases, for a year; age 60-79, HP positive peptic ulcer patients with 95 cases, group B for all patients. The first 2 times a day 400mg of metronidazole, amoxicillin 1000mg, esomeprazole treatment 20mg, duration 7d; then 1 times daily esomeprazole 20mg, to observe the application effect of the two groups after 21d.28d. Results: in the clinical symptoms first, the total efficiency of treatment was 91.49%, 84.21% in group B, the difference was statistically significant (P<0.05); in the ulcer healing treatment group, the total efficiency of 89.36%, 92.63% in group B, with statistical difference Significance (P>0.05). The Hp eradication rate, the eradication rate of 88.30%, 90.53% in group B, the difference was not statistically significant (P>0.05). In the aspect of adverse reactions, 1 cases of group a nausea, no other adverse reactions, the incidence rate was 1.06%; 3 cases in group B, 2 cases of headache, nausea, no appetite vibration in 5 cases, the incidence of adverse reaction rate of 10.53%. was statistically significant (P<0.05) conclusion: