Abstract: [Abstract] Objective To compare the clinical efficacy of different hyperbaric oxygen treatment methods in elderly patients with acute cerebral infarction. Methods 150 cases of elderly patients with acute cerebral infarction were randomly divided into three groups: control group, group I, group II, 50 cases in each group, respectively. The three groups were NIHHS, ADL and the FMA score was compared. Results three groups were NIHHS, ADL and FMA score before treatment were significantly improved (P<0.05) group, two patients in the treatment group were better than that in control group (P<0.05); the treatment group showed that group NIHHS patients, FMA score improved significantly better than the group I (P<0.05) treatment group. The total efficiency of the patients was significantly better than the control group (P<0.05), group II total efficiency is better than that of group I (P<0.05). Conclusion to the elderly patients with acute cerebral infarction underwent hyperbaric oxygen therapy can significantly improve symptoms and improve the total efficiency of treatment.