Abstract: Montelukast has the advantages of high efficacy，less adverse reactions and low drug dependence，and it is already as a first-line controller drug for the treatment of mild asthma in children， or prefered combination therapy with inhaled corticosteroids for moderate to severe asthma.However，there is no systematic choice criterion for the dose of the drug for children in different ages. This study summarized the domestic and foreign-related literature，based on the results of montelukast pharmacokinetic study， and the dose selection of montelukast was determined under the condition of considering the age and weight of the patients.The criteria for different doses of montelukast were formulated as follows：10 mg coated tablets for children over 15 years old and adults，5 mg chewable tablets for 6-14 years old，4 mg chewable tablets for 2-5 years old，4 mg granules for 1-5 years old.The aim of this study is to evaluate the dose selection criteria of montelukast children of different ages with asthmatic in order to provide reference for clinical treatment of children asthma.