Abstract: Objective：To analyze the effect of zhanjin huoxue san on the treatment of acute soft tissue injury of ankle. Methods： Sixty cases of patients with acute soft tissue injury of ankle in our hospital from June 2016 to February 2017 were randomly divided into the treatment group and the control group， thirty cases in each group. The patients in the treatment group were treated with zhanjin huoxue san while patients in the control group were treated with ibuprofen sustained-release capsules. Two weeks later the clinical effects of the two groups were observed and the pain scores swelling scores， tenderness scores， and disability scores before and after treatment were compared. Also， the imaging index of swelling attenuation T2 were observed and compared. Results：After two weeks of treatment， the clinical effective rate of treatment group reached 90.0% while the total efficiency of the control group was 53.3%. There was significant difference between the treatment group and the control group(P<0.05). After treatment， the pain scores， swelling scores， tenderness scores， and disability scores of the two groups were both significantly lower (P<0.05). However， except the swelling scores and tenderness scores， the analgesic efficacy between the two groups was the same. Thus， it showed no statistical significance (P>0.05). The MRI examination T2 values before and after the treatment were obviously different， which showed statistical significance(P<0.05). Furthermore， the treatment group changed more， statistically proving the differences between the treatment group and the control group (P<0.05). Conclusion：Zhanjin huoxue san can significantly relief the clinical symptoms of acute soft tissue injury in the ankle， and significantly improve the swelling imaging indexes， which should be clinically expanded.