Investigating the Causal Association Between Crohn’s Disease and Atrial Fibrillation Based on the Theory of

doi:magtech.2025.06.25-00002

Abstract

Abstract:

Objective： Based on the traditional Chinese medicine theory of "the heart and small intestine are interior-exteriorly related"， the Mendelian randomization （MR） method was used to explore the causal association between Crohn's disease （CD） and atrial fibrillation （AF） in the East Asian population， and to predict the potential traditional Chinese medicines that can intervene in AF by regulating CD.Methods： The genetic summary data of CD and AF were obtained from the IEU database. The TwoSampleMR software package in R language was used to perform MR analysis， and the inverse variance weighted method was mainly used to evaluate the genetic causal effect. Through the functional enrichment analysis of the neighboring genes of instrumental variables， the potential signaling pathways of CD in AF were explored. The Coremine database was used to predict the traditional Chinese medicines that have potential regulatory effects on these neighboring genes of instrumental variables， and their properties， flavors， meridian tropism and efficacy were statistically analyzed. Finally， by comparing with the most commonly used traditional Chinese medicines for the treatment of CD and AF in clinical practice， the intersection was identified to determine the final predicted traditional Chinese medicines.Results： The study found that CD was a risk factor for AF. The neighboring genes of instrumental variables were mainly enriched in regulating signaling pathways such as Th1， Th2， Th17 cells， MHC class Ⅱ molecules， endoplasmic reticulum， tumor necrosis factor receptor binding and cytokine receptors. The potential regulatory traditional Chinese medicines were mainly cold in the four natures， followed by warm and mild； in the five flavors， they were mainly bitter， followed by sweet and pungent； in terms of meridian tropism， they mainly involved the lung， followed by the spleen， liver and stomach； in terms of efficacy， they were mainly for tonifying deficiency， followed by clearing heat， resolving phlegm and stopping cough， promoting blood circulation to remove blood stasis and promoting diuresis and eliminating dampness. Through comparison with commonly used traditional Chinese medicines in clinical practice， Atractylodes macrocephala， Poria cocos， Glycyrrhiza uralensis， Coptis chinensis， Panax notoginseng， Citri reticulatae pericarpium and Astragalus membranaceus were finally determined as the final predicted traditional Chinese medicines.Conclusion： According to the classic traditional Chinese medicine theory of "the heart and small intestine are interior-exteriorly related"， the MR method confirmed that CD is a risk factor for AF in the East Asian population. This study revealed that CD affects the occurrence of AF by regulating Th1， Th2， Th17 cells， MHC class Ⅱ molecules， endoplasmic reticulum， tumor necrosis factor receptor binding and cytokine receptors. The study also found a variety of traditional Chinese medicines with potential regulatory effects， such as medicines for clearing heat， resolving phlegm and stopping cough， promoting blood circulation to remove blood stasis and promoting diuresis and eliminating dampness， which provides a new strategy for the prevention and treatment of CD-related AF with traditional Chinese medicine.

Key words: Crohn's disease； , Atrial fibrillation； , The heart and small intestine are interior-exteriorly related； , Same treatment for different diseases； , Mendelian randomization； , Genetic causal effect

CLC Number:

XIAO Sinan, ZHOU Ling, CAI Tao, CAO Ruoxi, LIU Fang, YANG Le, CAO Bo.

Investigating the Causal Association Between Crohn’s Disease and Atrial Fibrillation Based on the Theory of "Heart and Small Intestine are Interior-Exteriorly Related" and Prediction of Interventing Traditional Chinese Medicine [J]. CHINESE JOURNAL OF MEDICINAL GUIDE, 2025, 27(12): 1269-1269-1278.

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Investigating the Causal Association Between Crohn’s Disease and Atrial Fibrillation Based on the Theory of "Heart and Small Intestine are Interior-Exteriorly Related" and Prediction of Interventing Traditional Chinese Medicine

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