Abstract: Objective： To establish the fingerprint of Qing Nao Jiang Ya tablet， to determine the attribution of common chromatographic peaks in crude drugs， and to detect quantitatively the target components. Methods：High performance liquid chromatography (HPLC) and wave length detection were used. Results： 14 common chromatographic peaks were identified in the crude drugs. 8 chemical components were identified， and 2 kinds of indicators in the preparation were detected quantitatively. Tested by 2012 130723 edition “chromatographic fingerprint similarity evaluation system” software， the similarity of the 11 batches of Qing Nao Jiang Ya tablets is greater than 0.90； 2 index components (286 nm test， 254 nm test of salvianolic acid B and rutin) in the respective concentration range have good linear relationship (r=0.9997， 0.9999). Conclusion： The preparation and crude drugs have good correlation peaks. This method can be used for the quality control of Qing Nao Jiang Ya tablets， and offer reference for the research of other compound preparation.