Abstract: Objective： To explore the effect of thoracic paravertebral block combined with general anesthesia on promoting the resuscitation and improving the quality of early recovery of patients after combined thoracoscopic-laparoscopic esophagectomy for esophageal cancer patients. Methods： 80 patients with combined thoracoscopic-laparoscopic esophagectomy in the general thoracic surgery of our hospital from June 2015 to June 2019 were randomly divided into two groups. 40 patients in the experimental group were given paravertebral block combined with general anesthesia， and 40 patients in the control group were only given general anesthesia. All patients were given PCIA after surgery. The postoperative awaking time， the time of spontaneous respiration recovery， the time of orientation recovery and the time of extubation were recorded in the two groups. The number of self-pressing analgesia pump times， the average VAS score and the most painful VAS score of 24 h resting state pain， the incidence of adverse reactions such as nausea and vomiting， the satisfaction score， and the QoR-40 score of 24 h recovery quality of patients were also recorded in the two groups. Results： Compared with the control group， the recovery time and the extubatioin time of spontaneous breathing， the orientation recovery time and the extubatioin time of the experimental group were shorter， and the postoperative awaking time was faster. The QoR-40 score of the experimental group was higher than that of the control group， the average VAS score and the most painful VAS score were lower， the number of self-pressing analgesic pumps time was less， and the analgesic effect was better. In the experimental group， the incidence of postoperative adverse reactions was reduced， and patients′ satisfaction was improved. The difference of above indexes between the two groups had statistical significance (P<0.05).Conclusion： Paravertebral block combined with general anesthesia can promote the recovery of patients after combined thoracoscopic-laparoscopic esophagectomy， relieve postoperative pain， improve the quality of early recovery of patients， and reduce the incidence of postoperative nausea， vomiting， delirium， urinary retention and other adverse reactions. The clinical application is safe and the patient satisfaction is improved.