关键词: font-size:medium, ">何首乌；炮制；微波消解；电感耦合等离子体质谱；重金属及有害元素

Abstract: Objective： To establish an inductively coupled plasma mass spectrometry（ICP-MS）method for the determination of the content of 5 kinds of heavy metals and harmful elements [lead(Pb)， arsenic (As)， mercury (Hg)， cadmium (Cd)， and copper (Cu)] in Polygoni Multiflori Radix and processed product by semen sojae atricolor and rice wine， to provide accurate and reliable detection methods and basic data for quality control of processed Polygoni Multiflori Radix. Methods： The samples were digested by microwave and calibrated by internal standard elements including Ge，In and Bi， and were analyzed by ICP-MS．The determination conditions were as follows：ICP-MS power was 1.6 kW； the sampling depth was 17.0 mm，the carrier gas (high purity argon) flow rate was 1.1 L·min-1， the cooling gas velocity was 15.0 L·min-1， the auxiliary gas velocity was 1.0 L·min-1， and the sampling was scaned 20 times and repeated 3 times. Results： The 5 kinds of heavy metals and harmful elements showed good linearity within the selected concentration ranges (r≥0.997 5) with the average recovery from 82.18% to 108.36%，while their RSD were below or equal to 9.59%.The detection limits of the method were range from 0.014 to 0.15 μg·L-1. 5 batches of samples before and after processing contained different levels of Pb、As、Hg、Cd and Cu，but no significant change. Conclusion： The method is accurate and sensitive. The processing of Polygoni Multiflori Radix by Semen Sojae Atricolor and rice wine was safe and stable.

Key words: font-size:medium, ">Polygoni Multiflori Radix；Processing； Microwave digestion；Inductively coupled plasma mass spectrometry（ICP-MS）； Heavy metals and harmful elements