关键词: font-size:medium, ">新型冠状病毒；母婴垂直传播；胎盘；病理学；妊娠

Abstract: The presence of SARS-CoV-2 infection in pregnant women has potentially been associated with increased maternal morbidity and various placental abnormalities in a subset of patients. At present， the direct relationship between SARS-CoV-2 infection and placental lesions is not clear， but studies have confirmed that SARS-CoV-2 can cross the placental barrier and cause vertical transmission between mother and baby. Understanding the mechanisms underlying SARS-CoV-2 vertical transmision is critical for antenatal care and maternal-neonatal safety despite of its low occurence.Once the change of placental function and its impact on fetal growth are confirmed clinically， corresponding measures should be taken in time to minimize fetal death and other serious complications of mother and child. This study intends to review and analyze the published international literatures and the pathological research data of eight groups of placenta and some stillborn fetuses published on the 2022 annual meeting of USCAP and European Congress of Pathology， summarize and elaborate the existing scientific evidence， with a view to providing reference for understanding the impact of SARS-CoV-2 on pregnant women， and propose the future research direction for the vertical transmission of SARS-CoV-2: how does SARS-CoV-2 infect the fetus across the placenta; does vertical transmission occur in the early， middle or late pregnancy; after virus infection， placental function is abnormal， why do most pregnant women have no or no obvious influence; do different virus variants and different types of vaccination have different effects on infected pregnant women.

Key words: SARS-CoV-2, Vertical transmission, Placenta, Pathology;