关键词: font-size:medium, ">热激；新冠病毒；新冠肺炎；RNA依赖的RNA聚合酶（NSP12）；病毒复制

Abstract: According to real-time statistics from Johns Hopkins University in the United States， the cumulative confirmed cases of COVID-19 throughout the world have exceeded 488 million， with more than 6.1 million deaths. The global epidemic of COVID-19 has lasted for more than two years， and it has brought a huge impact to most countries. At the beginning of 2022， the joint team of professor Hua Naranmandura and professor Chih-Hung Hsu from Zhejiang University School of Medicine found for the first time that a relatively mild hyperthermia (40 ℃) could markedly induce degradation of the RNA-dependent RNA polymerase (also known as NSP12) of SARS-CoV-2 and its mutants， thereby inhibiting the virus replication. This finding suggests that hyperthermia at fever-range mild temperatures may be used as effective approach to reduce virus replication by degrading viral RNA polymerase， avoid its infection and spread， and even prevent COVID-19 patients from deterioration. This research highlight focuses on introducing this novel result from the aspects of molecular mechanism and potential applications， aiming to provide theoretical support and guidance for the subsequent clinical application of hyperthermia.

Key words: Hyperthermia, SARS-CoV-2, COVID-19, RNA-dependent RNA polymerase(NSP12), Viral replication