关键词: 湿秘, 肠道菌群, 胃肠动力, 糖脂代谢, 幽门螺杆菌感染

Abstract: Constipation is a disease characterized by prolonged defecation cycle， poor or difficult defecation . Damp constipation， as a special classification of constipation， is mainly manifested as the stool is not dry or sticky， the feeling of defecation is unpleasant， combined with the stagnant of Qi in the body， which is lingering and difficult to heal. There are many records about damp constipation in ancient medical books， and modern Chinese medicine scholars also have a lot of experience and discussion on this disease. The etiology of damp constipation can be divided into internal dampness and external dampness， and the pathogenesis is based on weakness of the spleen and stomach， marked by dampness blocking Qi， which lead to the failure of the conduction of the large intestine， and dregs stopping inside. The principles of clinical treatment are invigorating spleen， regulating Qi and dispelling dampness. Because dampness over a long period of time may generate dampness-heat or block yang Qi， clinical treatment should be clearing heat or Wenrun therapy. At present， the research of pathogenic dampness is distributed in various fields， and the co-acting factors of constipation mainly focus on four aspects： gut microbes， gastrointestinal motility， glycolipid metabolism， and HP infection， and the factors are influenced by each other. However， there is still a lack of systematic discussion and basic research on the pathogenesis of damp constipation in modern medicine. This study elaborates on damp constipation from the traceability of Chinese medicine name， etiology and pathogenesis， syndrome differentiation and treatment and the relevant influencing factors on modern medicine， which can provides certain reference for the subsequent further clinical research and treatment of damp constipation.

Key words: Damp constipation, Gut microbes, Gastrointestinal motility, Glycolipid metabolism