关键词: 早期肺癌, 肺功能, 并发症, 应激指标

Abstract:

Objective： To investigate the effects of four-hole unidirectional totally thoracoscopic surgery （TTS） anatomic lobectomy on early-stage lung cancer （LC） and its effects on complications and lung function. Methods：A total of 80 patients with early-stage LC treated in our hospital from May 2020 to May 2023 were selected as research objects and divided into two groups according to random number table method， with 40 cases in each group. The patients in group A underwent four-hole unidirectional TTS anatomic lobectomy， and  the patients in group B underwent three-port thoracoscopic lobectomy （TTTL）. The perioperative indexes， the pulmonary function indicators before and after operation ［diffusion lung capacity for carbon monoxide （DLCO）， forced vital capacity （FVC）， maximal voluntary ventilation （MVV）］， stress indicators ［interleukin-10 （IL-10）， tumor necrosis factor-alpha （TNF-α）， C-reactive protein （CRP）］， and the occurrence rate of complications were compared between the two groups of patients.Results： The intraoperative blood loss of patients in group A was lower than that of group B， and the operation duration and hospital stay were shorter than those of group B （P < 0.05）. 3 months after operation， the levels of FVC， DLCO and MVV of patients in group A were higher than those of group B （P < 0.05）. 1 day after surgery， the serum IL-10， TNF-α， and CRP levels of patients in group A were lower than those in group B （P < 0.05）. The occurrence rate of complications of group A was 5.00% （2/40）， which was lower than that of group B （22.50%， 9/40） （P < 0.05）.Conclusion： In the treatment of early-stage LC， four-hole unidirectional TTS anatomic lobectomy can further optimize perioperative indexes， reduce complications， and produce less stress response to the body compared with TTTL， and has less impact on lung function.

Key words: Early-stage lung cancer； , Lung function； , Complications； , Stress index