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中国医药导刊 ›› 2025, Vol. 27 ›› Issue (3): 227-231.

• 研究进展 • 上一篇    下一篇

冠心病相关炎症通路及抗炎治疗进展

范海, 王岳松, 董学滨*   

  1. 皖南医学院附属马鞍山医院(马鞍山市人民医院)心内科,安徽 马鞍山 243000
  • 收稿日期:2024-09-29 修回日期:2025-01-26 出版日期:2025-03-28 发布日期:2025-03-28
  • 基金资助:
    安徽省高等学校科学研究项目(2024AH051925);安徽医科大学校科研基金项目(2022xkj130)

Progress of Coronary Heart Disease-Related Inflammatory Pathways and Anti-Inflammatory Therapy

  1. Department of Cardiovascular Medicine Ma'anshan Hospital Affiliated to Wannan Medical College
    Ma'anshan People's Hospital), Anhui Maanshan 243000, China
  • Received:2024-09-29 Revised:2025-01-26 Online:2025-03-28 Published:2025-03-28

摘要:

冠心病是心内科的常见病及多发病,虽经规律的冠心病二级预防治疗,但致死率及致残率仍居高不下,迫切需要研究冠心病发生发展的机制及开发新的治疗药物。研究显示,炎症反应可能参与冠心病的全程,并加速冠心病的发生发展。目前大量研究正在揭示其具体机制,针对相关通道及炎症因子的抑制剂也在开发及研究中,以发现冠心病抗炎的最佳药物。研究指出,NLRP3炎症小体信号通路及PI3K信号通路等经典的炎症通路广泛参与冠心病发病过程,其下游炎症因子白介素1、白介素6及肿瘤坏死因子等是导致冠心病进展的直接因素。基于此,本研究对NLRP3炎症小体信号通路、PI3K/AKT信号通路、AMPK信息通路、NF-κB相关信号通路等冠心病抗炎治疗的信号通道及相关药物作一综述,以期为冠心病的治疗提供新的治疗思路及策略。


关键词: 冠心病, 炎症, 信号通路, 抗炎药物

Abstract:

Coronary heart disease is a common and frequently occurring disease in cardiology. Despite regular secondary prevention and treatment of coronary heart disease the mortality and disability rates of coronary heart disease remain high. Therefore it is urgent to study the new mechanisms of the occurrence and development of coronary heart disease and develop new therapeutic drugs. A large number of studies have shown that inflammatory response may be involved in the entire process of coronary heart disease and accelerate the occurrence and development of coronary heart disease. At present a large number of studies are revealing its specific mechanism inhibitors of related channels and inflammatory factors are also being developed and studied and in order to find the best anti-inflammatory drug for coronary heart disease. Studies have pointed out that classic inflammatory pathways such as the NLRP3 inflammasome signaling pathway and the PI3K signaling pathway are widely involved in the pathogenesis of coronary heart disease and their downstream inflammatory factors such as interleukin 1 interleukin 6 and tumor necrosis factor are direct factors leading to the progression of coronary heart disease. Based on this this paper reviews the signaling channels and related drugs for the anti-inflammatory treatment of coronary heart disease and intends to provide new therapeutic ideas and strategies for the treatment of coronary heart disease.


Key words:  ,  , Coronary heart disease , Inflammation , Signal pathway , Antiinflammatory drug

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