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中国医药导刊 ›› 2025, Vol. 27 ›› Issue (7): 681-688.

• 研究进展 • 上一篇    下一篇

桂枝及其配伍方剂治疗心衰的研究进展

王娟1, 牛嘉暄2, 赵英强1*   

  1. 1.天津中医药大学第二附属医院,天津 300250;2.沧州市中心医院,河北 沧州 061000
  • 收稿日期:2024-12-02 修回日期:2025-05-28 接受日期:2025-10-10 出版日期:2025-07-28 发布日期:2025-10-10
  • 基金资助:
    国家重点研发计划(2019YFC1710005)

Research Progress on the Treatment of Heart Failure with Cinnamomi Ramulus and Its Compound Formulas

WANG Juan1, NIU Jiaxuan2, ZHAO Yingqiang1*   

  1. 1.The Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300250, China
    2.Cangzhou Central Hospital Hebei Cangzhou 061000, China
  • Received:2024-12-02 Revised:2025-05-28 Accepted:2025-10-10 Online:2025-07-28 Published:2025-10-10
  • Supported by:

摘要:

心力衰竭(简称“心衰”)是由于多种原因导致的心脏结构和(或)功能异常,使心室收缩和(或)舒张功能发生障碍的一组临床综合征。心衰作为各种心脏疾病的终末阶段,已成为21世纪最重要的慢性心血管疾病之一。近年来治疗心衰以利尿剂、血管扩张剂、强心药及神经内分泌抑制剂等药物为主,虽可有效改善患者预后,但在安全性及疗效等方面仍有局限性。桂枝作为临床常见中药,广泛应用于心血管疾病的治疗,尤其在心衰的治疗上取得了较好的疗效。桂枝中含有的多种化学成分被证实可通过多种途径发挥治疗心衰的作用,主要包括抑制炎症反应、控制氧化应激、减少心肌细胞凋亡、减轻心肌纤维化、延缓心室重构等。临床上将桂枝与白芍、茯苓、甘草、黄芪等配伍形成复方,应用于心衰患者的治疗中,展现较好的疗效。本研究结合文献报道,从桂枝单体化学成分、桂枝配伍方剂2个方面总结桂枝及其配伍方剂在治疗心衰疾病中的应用,以期为桂枝治疗心衰的临床应用提供更全面的理论依据。

 

关键词: 桂枝, 心力衰竭, 桂皮醛, 配伍方剂

Abstract:

Heart failure is a group of clinical syndromes of disorders of ventricular contraction and or diastolic function due to abnormal structure and or function of the heart which is caused by a variety of reasons. As the end stage of various heart diseases it has become one of the most important chronic cardiovascular diseases in the 21st century. In recent years diuretics vasodilators cardiotonics and neuroendocrine inhibitors have been used to treat heart failure. Although they can effectively improve the prognosis of patients there are still limitations in terms of safety and efficacy. Cinnamomi Ramulus as a common traditional Chinese medicine in clinical practice has been widely used in the treatment of cardiovascular diseases and achieved good effects in the treatment of heart failure. The various chemical components contained in Cinnamomi Ramulus have been proven to exert therapeutic effects on heart failure through multiple pathways mainly including inhibiting inflammation controlling oxidative stress reducing myocardial apoptosis alleviating myocardial fibrosis and delaying ventricular remodeling. In clinical practiceCinnamomi Ramulus is commonly combined with white Peony root Poria Licorice and Astragalus to form compound formulas which have demonstrated significant therapeutic efficacy in the treatment of heart failure patients.This study based on the literature reports summarizes the application of Cinnamomi Ramulus and its compound formulas in the treatment of heart failure from the aspects of the monomer chemical composition of Cinnamomi Ramulus and the compound formulas of Cinnamomi Ramulus with the aim of providing a more comprehensive data basis for the clinical application of Cinnamomi Ramulus in the treatment of heart failure.


Key words: Cinnamomi Ramulus , Heart failure , Cinnamic aldehyde , Compound formulas

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