Abstract: Objective： To investigate the effects of vardenafil on peripheral blood inflammatory factors and oxidative stress in patients with sepsis after macrovascular surgery. Methods： 60 patients who were hospitalized in the ICU ward for sepsis after macrovascul surgery in our hospital from January to December 2018 were collected. They were divided into group A and group B， 30 cases each， according to different treatment methods. Patients in group A received conventional treatment， and patients in group B were treated with vardenafil on the basis of conventional treatment. 40 healthy patients who underwent health examination in our hospital during the same period were selected as group C. The levels of monocyte chemotactic protein-1 (MCP-1)， high-sensitivity C-reactive protein (Hs-CRP)， macrophage-derived chemokine (MDC)， and tumor necrosis factor (TNF-α) were detected by ELISA method， and the WST method， colorimetric method， and microplate method were used to detect the leves of malondialdehyde (MDA)， superoxide dismutase (SOD)， and glutathione (GSH). Differences in inflammatory factors and oxidative stress levels between the three groups were statistially and analyzed. Results： The MCP-1， MDC， Hs-CRP and TNF-α of the patients in group A and group B were decreased after treatment (P<0.05). Group B after treated with vardenafil， MCP-1， MDC， Hs-CRP and TNF-α were lower than those in group A (P<0.05). Compared with group A and group B before and after treatment， MCP-1， MDC， and Hs-CRP in group C were always at lower levels (P<0.05). Patients in group A and group B had increased GSH after treatment compared with before treatment， and SOD and MDA decreased (P<0.05). Serum SOD and MDA in group B were lower than those in group A， and GSH in group B was higher than that in group A(P<0.05). GSH in group C was significantly higher than those in group A and group B， and MDA and SOD were significantly lower than those in group A and group B (P<0.05). Conclusion： Oxidative stress response occurs in patients with sepsis after macrovascular surgery. Peripheral blood inflammatory factors are abnormally increased. After treatment with vardenafil， oxidative stress can be reduced to reduce the levels of inflammatory factors， which had good therapeutic effect on sepsis after macrovasular surgery.