疏血通联合乌司他丁治疗高脂血症性胰腺炎对肠道激素和脂肪因子的影响

摘要/Abstract

摘要： 目的：观察疏血通联合乌司他丁治疗高脂血症性胰腺炎的疗效，及其对肠道激素和脂肪因子的影响。方法：选择2017年1月至2019年12月在我院诊治的高脂血症性胰腺炎患者70例，按照随机数字法将患者分为观察组和对照组，每组各35例。对照组予以乌司他丁治疗，观察组在对照组的基础上予以疏血通注射液治疗。比较两组患者治疗后的疗效和临床指标，观察两组患者治疗前后甘油三酯（TG），急性生理及慢性健康状况Ⅱ（APACHEⅡ）评分、Balthazar CT评分、胃动素（MTL）、肠抑胃肽（GIP）、血管活性肠肽（VIP）、瘦素、网膜素-1和内脂素水平的变化。结果：观察组的总有效率为97.14%，对照组的总有效率为77.14%，观察组的疗效明显优于对照组（χ2=4.590，P<0.05）。观察组患者的腹痛缓解时间、肠鸣音恢复时间、肛门排气恢复时间、恢复进食时间、淀粉酶恢复时间和住院时间短于对照组（P<0.01）。两组患者治疗前TG、APACHEⅡ评分、Balthazar CT评分、MTL、GIP、VIP、瘦素、网膜素-1和内脂素水平差异无统计学意义（P>0.05），治疗后两组患者TG、APACHEⅡ评分、Balthazar CT评分、GIP、VIP、网膜素-1和内脂素水平均较治疗前降低（P<0.01），MTL和瘦素水平较治疗前升高（P<0.01），而观察组患者以上指标的降低或者升高较对照组更为明显（P<0.01）。结论：疏血通联合乌司他丁治疗高脂血症性胰腺炎疗效显著，有助于胃肠功能恢复、提高疗效，其机理可能与脂肪因子水平变化相关。

关键词: font-size:medium, ">疏血通注射液；乌司他丁；高脂血症性胰腺炎；肠道激素；脂肪因子

Abstract: Objective： To observe the efficacy of Shuxuetong combined with ulinastatin in the treatment of hyperlipidemic pancreatitis and its impact on intestinal hormones and adipokines. Methods： 70 patients with hyperlipidemic pancreatitis treated in our hospital from January 2017 to December 2019 were divided into the observation group and the control group according to random number method， and each group had 35 cases. The control group was treated with ulinastatin， and the observation group was treated with Shuxuetong injection on the basis of the treatment of the control group. The efficacy and clinical indicators were compared between the two groups after treatment， and the triglyceride (TG)， acute physiology and chronic health condition Ⅱ(APACHEⅡ) score， Balthazar CT score， motilin (MTL)， gastrointestinal peptide (GIP)， vasoactive intestinal peptide (VIP)， leptin， omentin-1， and visfatin levels were observed in the two groups before and after treatment. Results： The total effective rate was 97.14% in the observation group， and 77.14% in the control group. The efficacy in the observation group was significantly better than that of the control group (χ2=4.590， P<0.05). The abdominal pain relief time， bowel sound recovery time， anal exhaust recovery time， recovery eating time， amylase recovery time and hospital stay time in the observation group were significantly shorter than those in the control group (P<0.01). There were no statistical difference in TG， APACHEⅡ score， Balthazar CT score， MTL， GIP， VIP， leptin， omentin-1， and visfatin levels between the two groups before treatment (P>0.05). After treatment， the levels of TG， APACHEⅡ Scores， Balthazar CT scores， GIP， VIP， omentin-1， and visfatin in the two groups were lower than those before treatment (P<0.01)， and MTL and leptin levels were higher than those before treatment (P<0.01)， and the decrease or increase levels in the observation group was more significant than those in the control group (P<0.01). Conclusion： Shuxuetong combined with ulinastatin has obvious efficacy in the treatment of hyperlipidemic pancreatitis， which is helpful for the recovery of gastrointestinal function and improves the curative effect. Its mechanism may be related to the change of adipokines level.

Key words: font-size:medium, ">Shuxuetong injection； Ulinastatin； Hyperlipidemic pancreatitis； Intestinal hormones； Adipokines

中图分类号:

程明荣, 戴德坚. 疏血通联合乌司他丁治疗高脂血症性胰腺炎对肠道激素和脂肪因子的影响[J]. 中国医药导刊, 2020, 22(9): 615-619.

CHENG Mingrong, DAI Dejian. Impact of Shuxuetong Combined with Ulinastatin on Intestinal Hormones and Adipokines in the Treatment of Hyperlipidemic Pancreatitis[J]. CHINESE JOURNAL OF MEDICINAL GUIDE, 2020, 22(9): 615-619.

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