关键词: font-size:medium, ">社区卫生服务中心；药品不良反应；抗菌药物；合理用药

Abstract: Objective：To analyze the adverse reactions(ADRs) of antibacterial drugs reported by Shanghai Baoshan district community health service centers， and provide reference for clinical safe drug use. Methods： ADRs induced by antibacterial drugs reported by 16 community health service centers in Shanghai Baoshan district from January 2018 to December 2019 were collected from ADR monitoring database. The basic information of the patients， route of administration， drug types， system-organs involved in ADRs， and distribution of reporters′ occupations were analyzed retrospectively. Results: A total of 1 127 ADR reports were collected， involving 1 112 patients， among which the proportion of female patients was much higher than that of male patients (64.75% vs 35.25%)， and the proportion of elderly patients over 65 years old was the highest (51.53%). The main antibacterial drugs causing ADR were cephalosporins， quinolones and macrolides， and the top three were levofloxacin， azithromycin and cefuroxime， respectively. Oral administration was the most common route (52.71%). The clinical manifestations of ADR were pruritus， nausea and rash， mainly involving gastrointestinal system， skin and accessory system. ADRs were mainly reported by clinicians. Conclusion： Elderly female patients should be selected as the key population for ADR monitoring. In order to reduce the occurrence of ADR and ensure the safety of drug use， antibacterial drugs should be rationally used， the pharmaceutical care capacity of primary medical institutions should be improved， and the pharmaceutical care of key drugs and elderly patients should be strengthened.

Key words: Community health service centers, Adverse drug reaction, Antibacterial drugs, Rational drug use