关键词: font-size:medium, ">电感耦合等离子体质谱法（ICP-MS）；中药材；金属元素

Abstract: Objective：To establish a inductively coupled plasma mass spectrometry（ICP-MS）method for simultaneous determination of 15 metallic elements， Lithium(Li)， Beryllium(Be)， Cobalt(Co)， Nickel(Ni)， Arsenicum(As)， Selenium(Se)， Strontium(Sr)， Manganese(Mn)， Cadmium(Cd)， Zinc(Zn)， Aluminum(Al)， Thallium(Tl)， Plumbum(Pb)， Bismuth(Bi)， Cuprum(Cu)，in traditional Chinese medicinal materials. Methods： Samples of traditional Chinese medicinal materials were dried at 60℃ for 3 h and crushed for coarse powder. Accurately weighed 0.2 g coarse powder of the sample，and placed into the digestion tank for digestion.Finally， the metered volume should be fixed to 25 mL by water. The ICP-MS method was established to determine the contents of 15 metallic elements， and external standard method was used for quantification. The instrument parameters of ICP-MS were as follows：radio frequency(RF) power at 1150 W， atomizer flow rate of argon gas at 1.20 L·min-1， plasma flow rate of argon gas at 15 L·min-1，sampling depth at 8 mm. The reaction modes were standard mode and collision mode. Results：Under the optimal instrument conditions， the linearity was good for 15 metallic elements in the concentration range of 0-100 μg·L-1， and the correlative coefficients was higher than 0.999.The recovery rate ranged from 85.3% to 114.7%. The RSD for precision ranged from 0.68% to 5.65%. The detection limits were all lower than 0.047 μg·L-1. The verified data meet the requirements of the analytical method. Conclusion： The method is rapid， simple， reproducible and accurate， and can be used for the content determination of 15 metallic elements in traditional Chinese medicinal materials.

Key words: font-size:medium, ">Inductively coupled plasma mass spectrometry（ICP-MS）； Traditional Chinese medicinal materials； Metallic elements