关键词: font-size:medium, ">主动监测；集中监测；主动监测系统；哨点计划；中国医院药物警戒系统

Abstract: Objective： To provide some inspiration for the development of active drug safety surveillance in China by comparing the active drug safety surveillance practices of China and the United States in different periods. Methods：The literature and data related to the active drug safety surveillance practices of China and the United States in different periods were retrieved through databases such as CNKI， PubMed， and the official website of BCDSP， Sentinel， CHPS， and the similarities and differences between China and the United States practices in the form， scale and other aspects of active drug safety surveillance at different periods were analyzed. Results and Conclusion：The development path of active drug safety surveillance practices of China and the United States is basically the same. Both countries have experienced the process from centralized monitoring in hospitals to the construction of active surveillance systems. However， there is a large gap in the scale and standardization of active surveillance in different periods between the two countries.The reasons for this disparity are manifold， the development level of pharmaceutical industry， the perfection of laws and regulations， the strength of policy support and the condition of information infrastructure are all important factors that affect the development level of active drug safety surveillance. Therefore， on the basis of learning from advanced experience of the United States， a development path of active drug safety surveillance in line with the reality of China should be actively explored，to continuously improve the capacity of drug safety supervision.

Key words: font-size:medium, ">Active surveillance； Centralized monitoring； Active surveillance； Sentinel initiative； CHPS