关键词: 急性血栓性或浅静脉炎, 五味饮, 血热瘀结型, 炎症因子, 血液流变学

Abstract:

Objective： To observe the efficacy of modified wuwei decoction adjuvant therapy on blood heat stasis accumulation type of acute superficial vein thrombophlebitis （SVT）.Methods： 152 patients with acute SVT admitted in our hospital from January 2022 to April 2024 were selected. According to the random number table method， these patients were divided into the western medicine group （routine treatment， n=76） and the combined Chinese-western medicine group （modified wuwei decoction on the basis of the western medicine group， n=76）. The clinical efficacy， TCM symptoms scores， venous clinical severity score （VCSS）， hemorheological indicators （hematocrit， fibrinogen， plasma viscosity 100s， whole blood viscosity 200s） and serum inflammatory factors levels ［high-sensitivity C-reactive protein （hs-CRP）， interleukin-6 （IL-6）， tumor necrosis factor-α （TNF-α）］ before and after the treatment and the adverse reactions were compared between the two groups.Results： The total effective rate of treatment in the combined Chinese-western medicine group （97.37%） was higher than that in the western medicine group （88.16%） （P<0.05）. After treatment， the scores of TCM symptoms， the scores of VCSS， the levels of hematocrit， fibrinogen， plasma viscosity 100 s， whole blood viscosity 200 s， hs-CRP， IL-6 and TNF-α in both groups decreased compared with those before treatment （P<0.05）， and the decrease of the above indicators in the combined Chinese-western medicine group was greater than that in the western medicine group （P<0.05）. There were no statistically significant differences in the incidence rates of adverse reactions between the two groups of patients （P>0.05）.Conclusion： Modified wuwei decoction can effectively relieve the clinical symptoms and hemorheological indicators and reduce the levels of inflammatory factors in patients with SVT of blood heat stasis accumulation type， and it has certain efficacy on controlling the progression of SVT.

［Key Words］  

Key words: Acute superficial vein thrombophlebitis； , Wuwei decoction； , Blood heat stasis accumulation type； , Inflammatory factors； , Hemorheology