Abstract: As 2017 Yunnan province intelligen manufacturing pilot demonstration project， the construction of lyophilized powder injection intelligen manufacturing project has adopted “full supply chain integration， full information integration， and full automation integration” to deeply integrate intelligent manufacturing with pharmaceutical processes and management processes， perform quality control of the whole process， and data life cycle management at the same time. Because this project set is large in scale， large in investment， long in period， high in complexity and high in innovation requirements， the implementation of the project is a continuous improvement process， with difficulties and problems emerging in the process.To ensure quality， project management， especially Party A′s collaborative management and overall coordination， is the key to the success of the project. Aiming at the particularity of computerized information systems of pharmaceutical enterprises， this article redefines the quality management of information system projects， analyzes and summarizes the intelligent manufacturing or information system project management of pharmaceutical enterprises from the aspects of “program quality management methods” and “practice party quality management practice experience” for future reference.It is recommended that the project manager of Party A must have overall mind to understand intelligent manufacturing， give full play to comprehensive coordination capabilities， and first reflect the certainty over digitalization， and gradually realize the certainty of the physical information system (CPS). It is recommended that the planning and implementation of the project should not fall into extremes， such as don′t pursue extreme unmanned management and full coverage in advance. While pursuing advanced nature， fully consider applicability and economics， and make rational choices.